Institut Pasteur Prevention & Molecular Therapy of Human Diseases, 25-28 rue du Dr Roux, F-75015, Paris, France.
Future Microbiol. 2013 Nov;8(11):1391-403. doi: 10.2217/fmb.13.111.
Bordetella pertussis is a Gram-negative human-restricted bacterium that evolved from the broad-range mammalian pathogen, Bordetella bronchiseptica. It causes whooping cough or pertussis in humans, which is the most prevalent vaccine-preventable disease worldwide. The introduction of the pertussis whole-cell vaccination for young children, followed by the introduction of the pertussis acellular vaccination (along with booster vaccination) for older age groups, has affected the bacterial population and epidemiology of the disease. B. pertussis is relatively monomorphic worldwide, but nevertheless, different countries are facing different epidemiological evolutions of the disease. Although it is tempting to link vaccine-driven phenotypic and genotypic evolution of the bacterium to epidemiology, many other factors should be considered and surveillance needs to continue, in addition to studies investigating the impact of current clinical isolates on vaccine efficacy.
百日咳博德特氏菌是一种革兰氏阴性的人类专性细菌，它由广谱哺乳动物病原体支气管败血波氏杆菌进化而来。它在人类中引起百日咳或百日咳，这是世界上最普遍的可通过疫苗预防的疾病。为幼儿引入全细胞百日咳疫苗，随后为年龄较大的儿童引入百日咳无细胞疫苗（以及加强疫苗），这影响了疾病的细菌种群和流行病学。百日咳博德特氏菌在全球范围内相对单一，但尽管如此，不同国家仍面临着不同的疾病流行病学演变。尽管将细菌的疫苗驱动表型和基因型进化与流行病学联系起来很诱人，但还需要考虑许多其他因素，并且需要继续监测，除了研究当前临床分离株对疫苗效力的影响。
