Department of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg PO Box 100, SE-405 30 Gothenburg, Sweden.
Nat Rev Neurosci. 2013 Dec;14(12):839-50. doi: 10.1038/nrn3642. Epub 2013 Nov 8.
Synapses are constantly generated at a high rate in the developing, prepubescent brain. Newly generated glutamatergic synapses lack functional AMPA receptor-mediated transmission. Most of these 'AMPA-silent' synapses are eliminated during the developmental period, but some are specifically selected for AMPA unsilencing by correlated pre-and postsynaptic activity as the first step in a process that leads to stabilization of the synapse. Premature, or delayed, unsilencing of AMPA-silent synapses has been implicated in neurodevelopmental disorders, and abnormal generation of AMPA-silent synapses is associated with brain trauma, addiction and neurodegenerative disorders, further highlighting the importance of AMPA-silent synapses in brain pathology.
在发育中的青春期前大脑中，突触以高速率不断产生。新生成的谷氨酸能突触缺乏功能性 AMPA 受体介导的传递。这些“AMPA 沉默”突触中的大多数在发育期间被消除，但有些突触通过前后突触活动的相关性被专门选择用于 AMPA 去沉默，作为导致突触稳定的第一步。AMPA 沉默突触的过早或延迟去沉默与神经发育障碍有关，而 AMPA 沉默突触的异常产生与脑创伤、成瘾和神经退行性疾病有关，这进一步强调了 AMPA 沉默突触在脑病理学中的重要性。
