Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA.
Curr Opin Chem Biol. 2013 Dec;17(6):968-75. doi: 10.1016/j.cbpa.2013.10.018. Epub 2013 Nov 5.
As the major structural component of the extracellular matrix, collagen plays a crucial role in tissue development and regeneration. Since structural and metabolic abnormalities of collagen are associated with numerous debilitating diseases and pathologic conditions, the ability to target collagens of diseased tissues could lead to new diagnostics and therapeutics. Collagen is also a natural biomaterial widely used in drug delivery and tissue engineering, and construction of synthetic collagen-like materials is gaining interests in the biomaterials community. The unique triple helical structure of collagen has been explored for targeting collagen strands, and for engineering collagen-like functional assemblies and conjugates. This review focuses on the forefront of research activities in the use of the collagen mimetic peptide for both targeting and mimicking collagens via its triple helix mediated strand hybridization and higher order assembly.
作为细胞外基质的主要结构成分，胶原蛋白在组织发育和再生中起着至关重要的作用。由于胶原蛋白的结构和代谢异常与许多衰弱性疾病和病理状况有关，因此能够针对病变组织的胶原蛋白可能会带来新的诊断和治疗方法。胶原蛋白也是一种广泛用于药物输送和组织工程的天然生物材料，合成类似胶原蛋白的材料的构建在生物材料领域引起了关注。胶原蛋白独特的三螺旋结构已被用于靶向胶原蛋白链，并用于工程胶原蛋白样功能组件和缀合物。本综述重点介绍了使用胶原蛋白模拟肽通过其三螺旋介导的链杂交和高级组装来靶向和模拟胶原蛋白的前沿研究活动。
