Singh Variksha, Marimuthu Thashree, Makatini Maya M, Choonara Yahya E
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa.
Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag 3, PO WITS, Johannesburg 2050, South Africa.
Polymers (Basel). 2022 Dec 8;14(24):5371. doi: 10.3390/polym14245371.
Regenerative medicine is an active research sphere that focuses on the repair, regeneration, and replacement of damaged tissues and organs. A plethora of innovative wound dressings and skin substitutes have been developed to treat cutaneous wounds and are aimed at reducing the length or need for a hospital stay. The inception of biomaterials with the ability to interact with cells and direct them toward desired lineages has brought about innovative designs in wound healing and tissue engineering. This cellular engagement is achieved by cell cues that can be biochemical or biophysical in nature. In effect, these cues seep into innate repair pathways, cause downstream cell behaviours and, ultimately, lead to advantageous healing. This review will focus on biomolecules with encoded biomimetic, instructive prompts that elicit desired cellular domino effects to achieve advanced wound repair. The wound healing dressings covered in this review are based on functionalized biopolymeric materials. While both biophysical and biochemical cues are vital for advanced wound healing applications, focus will be placed on biochemical cues and in vivo or clinical trial applications. The biochemical cues aforementioned will include peptide therapy, collagen matrices, cell-based therapy, decellularized matrices, platelet-rich plasma, and biometals.
再生医学是一个活跃的研究领域，专注于受损组织和器官的修复、再生及替换。人们已研发出大量创新型伤口敷料和皮肤替代物来治疗皮肤伤口，旨在缩短住院时间或减少住院需求。具有与细胞相互作用并引导其分化为所需细胞谱系能力的生物材料的出现，为伤口愈合和组织工程带来了创新设计。这种细胞参与是通过本质上可以是生化或生物物理的细胞信号实现的。实际上，这些信号渗入固有修复途径，引发下游细胞行为，并最终导致有益的愈合。本综述将聚焦于具有编码仿生、指导性提示的生物分子，这些提示引发所需的细胞多米诺效应以实现先进的伤口修复。本综述涵盖的伤口愈合敷料基于功能化生物聚合物材料。虽然生物物理和生化信号对于先进的伤口愈合应用都至关重要，但将重点放在生化信号以及体内或临床试验应用上。上述生化信号将包括肽疗法、胶原蛋白基质、细胞疗法、脱细胞基质、富血小板血浆和生物金属。
