Nagle J F, Dilley R A
J Bioenerg Biomembr. 1986 Feb;18(1):55-64. doi: 10.1007/BF00743612.
It is proven that any model of localized protonmotive energy coupling that relies upon properties of a homogeneous surface phase must, when operated in the steady state, lead to bulk phase electrochemical potentials for protons that are as large as those required by the delocalized chemiosmotic theory. To obtain models consistent with experiments supporting localized energy coupling requires some kind of surface heterogeneity for the proton conducting pathways. Two general classes of heterogeneous surface models are mentioned. One class involves phase-separated lipid domains. The second class involves hydrogen-bonded chains in proteins that traverse the membrane laterally.
事实证明，任何依赖均匀表面相性质的局部质子动力能量耦合模型，在稳态运行时，都会导致质子的体相电化学势与离域化学渗透理论所要求的一样大。要获得与支持局部能量耦合的实验相一致的模型，质子传导途径需要某种表面异质性。文中提到了两类一般的异质表面模型。一类涉及相分离的脂质结构域。第二类涉及在膜中横向穿过的蛋白质中的氢键链。
