Argenzio R A, Miller N, von Engelhardt W
Am J Physiol. 1975 Oct;229(4):997-1002. doi: 10.1152/ajplegacy.1975.229.4.997.
The absorption of volatile fatty acids (VFA) and the influence of VFA on the net transport of inorganic electrolytes and water were examined in the temporarily isolated colon of the conscious goat. Perfusion of the colon with a solution similar in content to that normally present in the cecal outflow showed that the net absorption of VFA was more rapid than that of any other ion present in the solution. When the VFA were replaced with Cl, the net absorption of Na and water was reduced nearly twofold. Increasing the pH of the solution from 6.0 to 7.4 in the presence of VFA also resulted in a twofold decreased in the net transport of Na and water. Perfusion of the colon with a hypertonic solution resulted in approximately zero net water transport; however, the net absorption of Na and VFA continued at similar rates as before. These results support the concept that the colon primarily conserves solute followed by the passive movement of water. They also demonstrate that VFA are rapidly absorbed from the goat colon and indicate a striking influence of VFA on the net transport of Na and water. The presence of VFA in the large intestine may be important for normal absorptive function.
在清醒山羊的临时分离结肠中，研究了挥发性脂肪酸（VFA）的吸收以及VFA对无机电解质和水净转运的影响。用与盲肠流出物中正常存在的溶液成分相似的溶液灌注结肠，结果表明VFA的净吸收比溶液中存在的任何其他离子都要快。当VFA被Cl取代时，Na和水的净吸收减少了近两倍。在存在VFA的情况下，将溶液的pH从6.0提高到7.4也导致Na和水的净转运减少了两倍。用高渗溶液灌注结肠导致净水转运几乎为零；然而，Na和VFA的净吸收仍以与之前相似的速率继续。这些结果支持了这样的概念，即结肠主要保留溶质，随后水被动移动。它们还表明VFA从山羊结肠中迅速吸收，并表明VFA对Na和水的净转运有显著影响。大肠中VFA的存在可能对正常吸收功能很重要。
