Coombs D W, Saunders R L, Fratkin J D, Jensen L E, Murphy C A
J Neurosurg. 1986 Jun;64(6):890-4. doi: 10.3171/jns.1986.64.6.0890.
The use of hydromorphone and clonidine, delivered intrathecally by an implanted infusion pump, is described in a patient with intractable cancer pain. The patient was a 48-year-old woman with uterine cervical cancer-related pain that was poorly responsive to conventional oral narcotics. Hydromorphone was used because of the patient's history of morphine intolerance. When progressive intrathecal hydromorphone dosages were required, intrathecal clonidine (an alpha 2 adrenergic agonist) was infused concomitantly. Intrathecal hydromorphone and clonidine successfully controlled this patient's pain without the necessity to resort to destructive neurosurgery.
本文描述了一名患有顽固性癌痛的患者，通过植入式输注泵鞘内注射氢吗啡酮和可乐定的治疗情况。该患者为一名48岁女性，患有子宫颈癌相关疼痛，对传统口服麻醉剂反应不佳。由于患者有吗啡不耐受史，故使用氢吗啡酮。当需要逐渐增加鞘内注射氢吗啡酮的剂量时，同时输注鞘内可乐定（一种α2肾上腺素能激动剂）。鞘内注射氢吗啡酮和可乐定成功控制了该患者的疼痛，无需进行破坏性神经外科手术。
