当钙通过离散通道进入时，递质释放与突触前钙内流之间的关系。
Relationship between transmitter release and presynaptic calcium influx when calcium enters through discrete channels.
作者信息
Zucker R S, Fogelson A L
出版信息
Proc Natl Acad Sci U S A. 1986 May;83(9):3032-6. doi: 10.1073/pnas.83.9.3032.
Abstract
We have used a three-dimensional diffusion model of calcium entering the presynaptic nerve terminal through discrete channels to simulate experiments relating transmitter release to presynaptic calcium current. The relationship will be less than linear, or will curve downward, if calcium channels are well separated. It will resemble a power-law function with exponent less than the cooperativity of calcium action if channels are clustered closer together. Large presynaptic depolarizations elicit more release than small depolarizations admitting the same calcium influx. This occurs because large pulses open more channels near each other, with the result that the calcium concentration near release sites is greater, due to overlap of calcium diffusing from adjacent channels.
摘要
我们使用了一个三维扩散模型，该模型描述钙离子通过离散通道进入突触前神经末梢的过程，以此来模拟将递质释放与突触前钙电流相关联的实验。如果钙通道彼此间隔较远，那么这种关系将小于线性关系，或者会向下弯曲。如果通道聚集得更近，它将类似于幂律函数，其指数小于钙作用的协同性。较大的突触前去极化比允许相同钙内流的较小去极化引发更多的递质释放。出现这种情况是因为大的脉冲会打开彼此靠近的更多通道，结果是由于从相邻通道扩散来的钙发生重叠，释放位点附近的钙浓度更高。
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