Llinás R, Steinberg I Z, Walton K
Biophys J. 1981 Mar;33(3):289-321. doi: 10.1016/S0006-3495(81)84898-9.
A voltage clamp study has been performed in the presynaptic terminal of the squid stellate ganglion. After blockage of the voltage-dependent sodium and potassium conductances, an inward calcium current is demonstrated. Given a step-depolarization pulse, this voltage- and time-dependent conductance has an S-shaped onset. At the "break" of the voltage step, a rapid tail current is observed. From these results a kinetic model is generated which accounts for the experimental results and predicts for the time course and amplitude a possible calcium entry during presynaptic action potentials.
在乌贼星状神经节的突触前终末进行了电压钳研究。在阻断电压依赖性钠电导和钾电导后，证明存在内向钙电流。给予一个阶跃去极化脉冲时，这种电压和时间依赖性电导具有S形起始。在电压阶跃的“转折”处，观察到一个快速的尾电流。根据这些结果建立了一个动力学模型，该模型解释了实验结果，并预测了突触前动作电位期间可能的钙内流的时间进程和幅度。
