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Methotrexate for the treatment of generalized vitiligo.

作者信息

Alghamdi Khalid, Khurrum Huma

机构信息

Dermatology Department, Vitiligo Research Chair, College of Medicine, King Saud University, P.O. Box 240997, Riyadh 11322, Saudi Arabia ; Vitiligo Research Chair, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

Saudi Pharm J. 2013 Oct;21(4):423-4. doi: 10.1016/j.jsps.2012.12.003.

DOI:10.1016/j.jsps.2012.12.003
PMID:24227963
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3824946/
Abstract
摘要

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Methotrexate for the treatment of generalized vitiligo.甲氨蝶呤用于治疗泛发性白癜风。
Saudi Pharm J. 2013 Oct;21(4):423-4. doi: 10.1016/j.jsps.2012.12.003.
2
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Methotrexate for treatment of vitiligo.甲氨蝶呤用于治疗白癜风。
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Low-dose Methotrexate for Vitiligo.低剂量甲氨蝶呤治疗白癜风
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PTPN22 is genetically associated with risk of generalized vitiligo, but CTLA4 is not.蛋白酪氨酸磷酸酶非受体型22基因（PTPN22）与泛发性白癜风风险存在遗传关联，但细胞毒性T淋巴细胞相关蛋白4（CTLA4）则不然。
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Combination therapy of orally administered glycyrrhizin and UVB improved active-stage generalized vitiligo.口服甘草酸苷与紫外线B联合治疗改善进展期泛发性白癜风。
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本文引用的文献

1
Unstable vitiligo responding to methotrexate.对甲氨蝶呤有反应的不稳定型白癜风。
Indian J Dermatol Venereol Leprol. 1998 Nov-Dec;64(6):309.
2
A review and a new hypothesis for non-immunological pathogenetic mechanisms in vitiligo.白癜风非免疫发病机制的综述与新假说
Pigment Cell Res. 2006 Oct;19(5):406-11. doi: 10.1111/j.1600-0749.2006.00333.x.
3
Increased tumor necrosis factor alpha (TNF-alpha) and interleukin 1 alpha (IL1-alpha) levels in the lesional skin of patients with nonsegmental vitiligo.非节段性白癜风患者皮损皮肤中肿瘤坏死因子α（TNF-α）和白细胞介素1α（IL1-α）水平升高。
Int J Dermatol. 2006 Aug;45(8):992-3. doi: 10.1111/j.1365-4632.2006.02744.x.
4
Immunological pathomechanisms in vitiligo.白癜风的免疫病理机制
Expert Rev Mol Med. 2001 Jul 23;3(20):1-22. doi: 10.1017/S1462399401003362.
5
Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.甲氨蝶呤通过抑制IκBα磷酸化和降解来抑制NF-κB激活。
J Immunol. 2001 Sep 1;167(5):2911-20. doi: 10.4049/jimmunol.167.5.2911.
6
Response to methotrexate in early rheumatoid arthritis is associated with a decrease of T cell derived tumour necrosis factor alpha, increase of interleukin 10, and predicted by the initial concentration of interleukin 4.早期类风湿关节炎对甲氨蝶呤的反应与T细胞衍生的肿瘤坏死因子α减少、白细胞介素10增加相关，且由白细胞介素4的初始浓度预测。
Ann Rheum Dis. 2000 Apr;59(4):311-4. doi: 10.1136/ard.59.4.311.
7
Treatment of pemphigus vulgaris with methotrexate.用甲氨蝶呤治疗寻常型天疱疮。
Arch Dermatol. 1969 Jul;100(1):70-8.