shurygina L V, Zlishcheva É I, Kravtsov A A, Androsova T V, Poleshchuk L A, Abramova N O, Zlishcheva L I
Eksp Klin Farmakol. 2013;76(8):9-12.
The influence of a new substance, lithium salt of comenic acid, on the oxidative processes in the brain of animals under the conditions of acute and long combined stress has been investigated. It is established that lithium comenate (1 and 2 mg/kg) exhibits pronounced dose-dependent antioxidative stress-protective effect, which is manifested in suppression of the hyperproduction of free radicals and depression of the content of malonic dialdehyde (a secondary product of lipid peroxidation) in the brain of stressed animals. The maximum antioxidative stress protection effect under the conditions of acute and long combined stress has been observed for lithium salt ofcomenic acid in a dose of 2 mg/kg.
研究了一种新物质——科美酸锂盐在急性和长期复合应激条件下对动物大脑氧化过程的影响。已确定科美酸锂（1和2毫克/千克）表现出明显的剂量依赖性抗氧化应激保护作用，这表现为抑制应激动物大脑中自由基的过度产生以及降低丙二醛（脂质过氧化的次级产物）的含量。在急性和长期复合应激条件下，观察到2毫克/千克剂量的科美酸锂盐具有最大的抗氧化应激保护作用。
