• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
Complex diseases require complex therapies.复杂疾病需要复杂的治疗方法。
EMBO Rep. 2013 Dec;14(12):1039-42. doi: 10.1038/embor.2013.177. Epub 2013 Nov 15.
2
Systems pharmacology in drug development and therapeutic use - A forthcoming paradigm shift.药物研发与治疗应用中的系统药理学——即将到来的范式转变。
Eur J Pharm Sci. 2016 Oct 30;94:1-3. doi: 10.1016/j.ejps.2016.07.014. Epub 2016 Jul 21.
3
Developing new drug treatments in the era of network medicine.网络医学时代新药治疗方法的开发
Clin Pharmacol Ther. 2013 Jan;93(1):26-8. doi: 10.1038/clpt.2012.207. Epub 2012 Oct 15.
4
Marc Kirschner. Interview by Asher Mullard.马克·基尔希纳。阿舍·穆拉德采访。
Nat Rev Drug Discov. 2011 Dec 1;10(12):894. doi: 10.1038/nrd3613.
5
Discovering the targets of drugs via computational systems biology.通过计算系统生物学发现药物的靶点。
J Biol Chem. 2011 Jul 8;286(27):23653-8. doi: 10.1074/jbc.R110.174797. Epub 2011 May 12.
6
[System biology and synthetic biology modify drug discovery and development].[系统生物学与合成生物学改变药物发现与开发]
Med Sci (Paris). 2012 Feb;28(2):207-12. doi: 10.1051/medsci/2012282020. Epub 2012 Feb 27.
7
GPS for QSP: A Summary of the ACoP6 Symposium on Quantitative Systems Pharmacology and a Stage for Near-Term Efforts in the Field.用于定量系统药理学的GPS:ACoP6定量系统药理学术研讨会综述及该领域近期工作进展
CPT Pharmacometrics Syst Pharmacol. 2016 Sep;5(9):449-51. doi: 10.1002/psp4.12109. Epub 2016 Sep 17.
8
Who will take up the gauntlet? Challenges and opportunities for systems biology and drug discovery.谁将接受这一挑战?系统生物学与药物发现面临的挑战与机遇。
EMBO Rep. 2009 Aug;10 Suppl 1(Suppl 1):S9-13. doi: 10.1038/embor.2009.132.
9
Systems pharmacology meets predictive, preventive, personalized and participatory medicine.系统药理学与预测、预防、个性化和参与性医学相遇。
Pharmacogenomics. 2013 Jan;14(2):119-22. doi: 10.2217/pgs.12.186.
10
Systems pharmacology to predict drug safety in drug development.用于预测药物研发中药物安全性的系统药理学。
Eur J Pharm Sci. 2016 Oct 30;94:93-95. doi: 10.1016/j.ejps.2016.05.027. Epub 2016 May 29.

引用本文的文献

1
Systems biology platform for efficient development and translation of multitargeted therapeutics.用于多靶点治疗药物高效研发与转化的系统生物学平台。
Front Syst Biol. 2023 Sep 18;3:1229532. doi: 10.3389/fsysb.2023.1229532. eCollection 2023.
2
A deep generative model for deciphering cellular dynamics and in silico drug discovery in complex diseases.一种用于解析复杂疾病中细胞动力学和计算机辅助药物发现的深度生成模型。
Nat Biomed Eng. 2025 Jun 20. doi: 10.1038/s41551-025-01423-7.
3
Artificial intelligence: A new tool in the pathologist's armamentarium for the diagnosis of IBD.人工智能:病理学家诊断炎症性肠病的新工具。
Comput Struct Biotechnol J. 2024 Sep 11;23:3407-3417. doi: 10.1016/j.csbj.2024.09.003. eCollection 2024 Dec.
4
Focus on Achalasia in the Omics Era.聚焦于组学时代的贲门失弛缓症。
Int J Mol Sci. 2024 Sep 21;25(18):10148. doi: 10.3390/ijms251810148.
5
Inflammatory bowel disease genomics, transcriptomics, proteomics and metagenomics meet artificial intelligence.炎症性肠病基因组学、转录组学、蛋白质组学和宏基因组学与人工智能相遇。
United European Gastroenterol J. 2024 Dec;12(10):1461-1480. doi: 10.1002/ueg2.12655. Epub 2024 Aug 31.
6
A combination treatment based on drug repurposing demonstrates mutation-agnostic efficacy in pre-clinical retinopathy models.基于药物重定位的联合治疗在临床前视网膜病变模型中显示出针对突变的疗效。
Nat Commun. 2024 Jul 15;15(1):5943. doi: 10.1038/s41467-024-50033-5.
7
approaches open new horizons in major depressive disorder: from biomarkers to precision medicine.治疗方法为重度抑郁症开拓新视野:从生物标志物到精准医学。
Front Psychiatry. 2024 Jun 13;15:1422939. doi: 10.3389/fpsyt.2024.1422939. eCollection 2024.
8
Molecular characterization of allergic constitution based on network pharmacology and multi-omics analysis methods.基于网络药理学和多组学分析方法的过敏体质的分子特征。
Medicine (Baltimore). 2024 Feb 16;103(7):e36892. doi: 10.1097/MD.0000000000036892.
9
Omics and Multi-Omics in IBD: No Integration, No Breakthroughs.炎症性肠病中的组学和多组学:没有整合,就没有突破。
Int J Mol Sci. 2023 Oct 5;24(19):14912. doi: 10.3390/ijms241914912.
10
RRx-001: a chimeric triple action NLRP3 inhibitor, Nrf2 inducer, and nitric oxide superagonist.RRx-001:一种嵌合型三重作用的NLRP3抑制剂、Nrf2诱导剂和一氧化氮超激动剂。
Front Oncol. 2023 May 29;13:1204143. doi: 10.3389/fonc.2023.1204143. eCollection 2023.

本文引用的文献

1
Systems pharmacology of adverse event mitigation by drug combinations.药物组合缓解不良事件的系统药理学。
Sci Transl Med. 2013 Oct 9;5(206):206ra140. doi: 10.1126/scitranslmed.3006548.
2
Pipeline for COPD drugs flows with combination candidates.慢性阻塞性肺疾病(COPD)药物研发流程中涌现出多种联合用药候选方案。
Nat Med. 2013 Sep;19(9):1079. doi: 10.1038/nm0913-1079.
3
Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop.饥饿状态通过突触 AMPK 依赖性正反馈回路切换翻转式记忆电路。
Cell. 2011 Sep 16;146(6):992-1003. doi: 10.1016/j.cell.2011.07.039.
4
T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia.嵌合抗原受体 T 细胞具有强大的抗肿瘤作用,并能在晚期白血病患者中建立记忆。
Sci Transl Med. 2011 Aug 10;3(95):95ra73. doi: 10.1126/scitranslmed.3002842.
5
Detecting drug interactions from adverse-event reports: interaction between paroxetine and pravastatin increases blood glucose levels.从不良反应报告中检测药物相互作用:帕罗西汀和普伐他汀相互作用会增加血糖水平。
Clin Pharmacol Ther. 2011 Jul;90(1):133-42. doi: 10.1038/clpt.2011.83. Epub 2011 May 25.
6
Interactome networks and human disease.相互作用组网络与人类疾病。
Cell. 2011 Mar 18;144(6):986-98. doi: 10.1016/j.cell.2011.02.016.
7
A positive feedback signal transduction loop determines timing of cerebellar long-term depression.一个正反馈信号转导环路决定小脑长时程抑制的时机。
Neuron. 2008 Aug 28;59(4):608-20. doi: 10.1016/j.neuron.2008.06.026.
8
Toward predictive models of mammalian cells.迈向哺乳动物细胞的预测模型。
Annu Rev Biophys Biomol Struct. 2005;34:319-49. doi: 10.1146/annurev.biophys.34.040204.144415.
9
Signaling networks: the origins of cellular multitasking.信号网络:细胞多任务处理的起源
Cell. 2000 Oct 13;103(2):193-200. doi: 10.1016/s0092-8674(00)00112-4.
10
Emergent properties of networks of biological signaling pathways.生物信号通路网络的涌现特性。
Science. 1999 Jan 15;283(5400):381-7. doi: 10.1126/science.283.5400.381.

Complex diseases require complex therapies.

作者信息

Iyengar Ravi

机构信息

Department of Pharmacology and Systems Therapeutics, Systems Biology Centre New York, Icahn School of Medicine in New York, New York, USA.

出版信息

EMBO Rep. 2013 Dec;14(12):1039-42. doi: 10.1038/embor.2013.177. Epub 2013 Nov 15.

DOI:10.1038/embor.2013.177
PMID:24232184
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3981088/
Abstract
摘要