Howard Hughes Medical Institute, Department of Pharmacology, University of Washington School of Medicine, Seattle, WA, USA.
Trends Pharmacol Sci. 2013 Dec;34(12):648-55. doi: 10.1016/j.tips.2013.10.005. Epub 2013 Nov 12.
A-kinase anchoring proteins (AKAPs) streamline signal transduction by localizing signaling enzymes with their substrates. Great strides have been made in elucidating the role of these macromolecular signaling complexes as new binding partners and novel AKAPs are continually being uncovered. The mechanics and dynamics of these multi-enzyme assemblies suggest that AKAP complexes are viable targets for therapeutic intervention. This review will highlight recent advances in AKAP research focusing on local signaling events that are perturbed in disease.
锚定蛋白激酶（AKAPs）通过将信号酶与其底物定位在一起，简化了信号转导。在阐明这些大分子信号复合物作为新的结合伴侣的作用方面已经取得了巨大进展，并且不断发现新的 AKAP。这些多酶组装体的力学和动力学表明，AKAP 复合物是治疗干预的可行靶点。本综述将重点介绍 AKAP 研究的最新进展，关注疾病中失调的局部信号事件。
