Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Żurawia 14, 15-540 Bialystok, Poland.
Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Żurawia 14, 15-540 Bialystok, Poland.
Immunol Lett. 2014 Jan-Feb;157(1-2):45-50. doi: 10.1016/j.imlet.2013.11.002. Epub 2013 Nov 12.
Knowledge of the role of chemokines in the inflammation during neuroborreliosis (NB) is limited. We evaluated the pre- and post-treatment concentration of CXCL8, CXCL10, CXCL11, CXCL12, and CXCL13 in serum (s) and cerebrospinal fluid (csf) in patients with NB.
There was a statistically significant increase in pre-treatment s CXCL8, CXCL10, CXCL11, CXCL12, CXCL13 and csf CXCL8, CXCL11, CXCL12, CXCL13 in patients with early form of NB. CXCL8, CXCL11, CXCL12 and CXCL13 increase was the highest in csf. After treatment, a significant decrease in csf chemokine levels (except CXCL10) and s levels (except CXCL11) was observed.
CXCL8, CXCL10, CXCL11, CXCL12, CXCL13 are involved in the pathomechanism of NB but their role is different in s and csf. CXCL13 seems to be a good biomarker for NB. In early NB, it may facilitate the diagnosis and monitoring of therapy. However tick-borne encephalitis needs to be excluded as it also increases chemokine concentration. Decrease in all examined chemokines in s and csf after treatment suggests that chemokines may be useful in monitoring response to NB therapy.
关于趋化因子在神经莱姆病（NB）炎症过程中的作用，目前我们知之甚少。本研究评估了 NB 患者治疗前后血清（s）和脑脊液（csf）中 CXCL8、CXCL10、CXCL11、CXCL12 和 CXCL13 的浓度。
早期 NB 患者治疗前 s CXCL8、CXCL10、CXCL11、CXCL12、CXCL13 和 csf CXCL8、CXCL11、CXCL12、CXCL13 水平显著升高。治疗后 csf 趋化因子水平（除 CXCL10 外）和 s 水平（除 CXCL11 外）显著降低。
CXCL8、CXCL10、CXCL11、CXCL12、CXCL13 参与了 NB 的发病机制，但它们在 s 和 csf 中的作用不同。CXCL13 似乎是 NB 的良好生物标志物。在早期 NB 中，它可能有助于诊断和监测治疗。但需要排除蜱传脑炎，因为它也会增加趋化因子浓度。治疗后 s 和 csf 中所有检查的趋化因子水平降低表明，趋化因子可能有助于监测 NB 治疗的反应。
