评价神经莱姆病患者血清和脑脊液中 CXCL8、CXCL10、CXCL11、CXCL12 和 CXCL13 的水平。

Evaluation of CXCL8, CXCL10, CXCL11, CXCL12 and CXCL13 in serum and cerebrospinal fluid of patients with neuroborreliosis.

机构信息

Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Żurawia 14, 15-540 Bialystok, Poland.

出版信息

Immunol Lett. 2014 Jan-Feb;157(1-2):45-50. doi: 10.1016/j.imlet.2013.11.002. Epub 2013 Nov 12.

DOI:10.1016/j.imlet.2013.11.002

PMID:24239846

Abstract

PURPOSE

Knowledge of the role of chemokines in the inflammation during neuroborreliosis (NB) is limited. We evaluated the pre- and post-treatment concentration of CXCL8, CXCL10, CXCL11, CXCL12, and CXCL13 in serum (s) and cerebrospinal fluid (csf) in patients with NB.

RESULTS

There was a statistically significant increase in pre-treatment s CXCL8, CXCL10, CXCL11, CXCL12, CXCL13 and csf CXCL8, CXCL11, CXCL12, CXCL13 in patients with early form of NB. CXCL8, CXCL11, CXCL12 and CXCL13 increase was the highest in csf. After treatment, a significant decrease in csf chemokine levels (except CXCL10) and s levels (except CXCL11) was observed.

CONCLUSIONS

CXCL8, CXCL10, CXCL11, CXCL12, CXCL13 are involved in the pathomechanism of NB but their role is different in s and csf. CXCL13 seems to be a good biomarker for NB. In early NB, it may facilitate the diagnosis and monitoring of therapy. However tick-borne encephalitis needs to be excluded as it also increases chemokine concentration. Decrease in all examined chemokines in s and csf after treatment suggests that chemokines may be useful in monitoring response to NB therapy.

摘要

目的

关于趋化因子在神经莱姆病（NB）炎症过程中的作用，目前我们知之甚少。本研究评估了 NB 患者治疗前后血清（s）和脑脊液（csf）中 CXCL8、CXCL10、CXCL11、CXCL12 和 CXCL13 的浓度。

结果

早期 NB 患者治疗前 s CXCL8、CXCL10、CXCL11、CXCL12、CXCL13 和 csf CXCL8、CXCL11、CXCL12、CXCL13 水平显著升高。治疗后 csf 趋化因子水平（除 CXCL10 外）和 s 水平（除 CXCL11 外）显著降低。

结论

CXCL8、CXCL10、CXCL11、CXCL12、CXCL13 参与了 NB 的发病机制，但它们在 s 和 csf 中的作用不同。CXCL13 似乎是 NB 的良好生物标志物。在早期 NB 中，它可能有助于诊断和监测治疗。但需要排除蜱传脑炎，因为它也会增加趋化因子浓度。治疗后 s 和 csf 中所有检查的趋化因子水平降低表明，趋化因子可能有助于监测 NB 治疗的反应。