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用于研究抗病毒药物预防潜伏性单纯疱疹病毒再激活效果的体外系统。

In vitro system for studying the efficacy of antiviral agents in preventing the reactivation of latent herpes simplex virus.

作者信息

Wohlenberg C, Openshaw H, Notkins A L

出版信息

Antimicrob Agents Chemother. 1979 Apr;15(4):625-7. doi: 10.1128/AAC.15.4.625.

DOI:10.1128/AAC.15.4.625
PMID:223499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352721/
Abstract

Antiviral antibody and interferon did not prevent in vitro reactivation of herpes simplex virus in latently infected sensory ganglia. Phosphonoacetic acid and 9-beta-d-arabinofuranosyladenine blocked reactivation, but this treatment did not eradicate the latent infection.

摘要

抗病毒抗体和干扰素不能阻止潜伏感染的感觉神经节中单纯疱疹病毒的体外再激活。膦甲酸和9-β-D-阿拉伯呋喃糖基腺嘌呤可阻断再激活，但这种治疗并不能根除潜伏感染。

相似文献

1
In vitro system for studying the efficacy of antiviral agents in preventing the reactivation of latent herpes simplex virus.用于研究抗病毒药物预防潜伏性单纯疱疹病毒再激活效果的体外系统。
Antimicrob Agents Chemother. 1979 Apr;15(4):625-7. doi: 10.1128/AAC.15.4.625.
2
Effect of acyclovir, bromovinyldeoxyuridine, vidarabine, and L-lysine on latent ganglionic herpes simplex virus in vitro.阿昔洛韦、溴乙烯脱氧尿苷、阿糖腺苷和L-赖氨酸对体外潜伏神经节单纯疱疹病毒的作用。
Am J Med. 1982 Jul 20;73(1A):151-4. doi: 10.1016/0002-9343(82)90081-x.
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Treatment of experimental latent herpes simplex virus infections with acyclovir and other antiviral compounds.用阿昔洛韦和其他抗病毒化合物治疗实验性潜伏单纯疱疹病毒感染。
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Effect of acyclovir on latent herpes simplex virus infections in trigeminal ganglia of mice.阿昔洛韦对小鼠三叉神经节中潜伏性单纯疱疹病毒感染的影响。
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Acute and latent infection of sensory ganglia with herpes simplex virus: immune control and virus reactivation.单纯疱疹病毒对感觉神经节的急性和潜伏感染：免疫控制与病毒再激活
J Gen Virol. 1979 Jul;44(1):205-15. doi: 10.1099/0022-1317-44-1-205.
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Efficacy of phosphonoacetic acid on herpes simplex virus infection of sensory ganglia.膦甲酸钠对感觉神经节单纯疱疹病毒感染的疗效。
Infect Immun. 1976 May;13(5):1519-21. doi: 10.1128/iai.13.5.1519-1521.1976.
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Effect of eight antiviral drugs on the reactivation of herpes simplex virus in explant cultures of latently infected mouse trigeminal ganglia.八种抗病毒药物对潜伏感染小鼠三叉神经节外植体培养物中单纯疱疹病毒再激活的影响。
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Experimental skin infection with an acyclovir resistant herpes simplex virus mutant: response to antiviral treatment and protection against reinfection.用阿昔洛韦耐药单纯疱疹病毒突变体进行实验性皮肤感染：对抗病毒治疗的反应及预防再感染
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In vitro effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5'-amino-5-iodo-2',5'-dideoxyuridine and 2-deoxy-D-glucose on latent ganglionic herpes simplex virus infection.（E）-5-（2-溴乙烯基）-2'-脱氧尿苷、5'-氨基-5-碘-2'，5'-二脱氧尿苷和2-脱氧-D-葡萄糖对潜伏性神经节单纯疱疹病毒感染的体外作用。
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Herpes simplex virus type 2 latency in the footpad of mice: effect of acycloguanosine on the recovery of virus.2型单纯疱疹病毒在小鼠足垫中的潜伏：阿昔洛韦对病毒恢复的影响。
J Gen Virol. 1988 Feb;69 ( Pt 2):433-8. doi: 10.1099/0022-1317-69-2-433.

引用本文的文献

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Infect Immun. 1983 Aug;41(2):702-8. doi: 10.1128/iai.41.2.702-708.1983.
2
Effect of acyclovir on latent herpes simplex virus infections in trigeminal ganglia of mice.阿昔洛韦对小鼠三叉神经节中潜伏性单纯疱疹病毒感染的影响。
Antimicrob Agents Chemother. 1981 May;19(5):937-9. doi: 10.1128/AAC.19.5.937.
3
Persistence of herpes simplex virus (HSV) infection in ganglia and peripheral tissues of guinea pigs.单纯疱疹病毒（HSV）在豚鼠神经节和外周组织中的持续性感染。
Med Microbiol Immunol. 1981;169(2):91-6. doi: 10.1007/BF02171776.
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Antimicrob Agents Chemother. 1985 May;27(5):763-8. doi: 10.1128/AAC.27.5.763.
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Modulation of acute and latent herpes simplex virus infection in C57BL/6 mice by adoptive transfer of immune lymphocytes with cytolytic activity.通过具有细胞溶解活性的免疫淋巴细胞的过继转移对C57BL/6小鼠急性和潜伏性单纯疱疹病毒感染的调节
J Virol. 1989 Mar;63(3):1480-4. doi: 10.1128/JVI.63.3.1480-1484.1989.
6
Effects of 2,2'-O-cyclocytidine and acyclovir on latent herpes simplex virus in trigeminal ganglia of mice.2,2'-O-环胞苷和阿昔洛韦对小鼠三叉神经节中潜伏单纯疱疹病毒的影响。
Antimicrob Agents Chemother. 1986 Feb;29(2):278-80. doi: 10.1128/AAC.29.2.278.

本文引用的文献

1
Activation of latent herpes simplex by trigeminal sensory-root section.通过三叉神经感觉根切断术激活潜伏的单纯疱疹病毒。
N Engl J Med. 1952 Jan 31;246(5):172-6. doi: 10.1056/NEJM195201312460503.
2
Immune mechanisms by which the spread of viral infections is stopped.阻止病毒感染传播的免疫机制。
Cell Immunol. 1974 Mar 30;11(1-3):478-83. doi: 10.1016/0008-8749(74)90045-8.
3
Latent ganglionic infection with herpes simplex virus types 1 and 2: viral reactivation in vivo after neurectomy.1型和2型单纯疱疹病毒的潜伏性神经节感染：神经切除术后体内的病毒再激活
Science. 1974 Jun 14;184(4142):1185-7. doi: 10.1126/science.184.4142.1185.
4
Persistent herpes simplex virus infection in rabbit trigeminal ganglia.兔三叉神经节中的持续性单纯疱疹病毒感染
Lab Invest. 1974 Feb;30(2):230-40.
5
Latent herpes simplex virus in spinal ganglia of mice.小鼠脊髓神经节中的潜伏性单纯疱疹病毒
Science. 1971 Aug 27;173(3999):843-5. doi: 10.1126/science.173.3999.843.
6
Heterogeneity in the properties of 7 S and 19S rabbit-neutralizing antibodies to herpes simplex virus.兔抗单纯疱疹病毒7S和19S中和抗体特性的异质性
J Immunol. 1968 Mar;100(3):586-93.
7
Rational design of arabinosyl nucleosides as antitumor and antiviral agents.阿拉伯糖基核苷作为抗肿瘤和抗病毒药物的合理设计。
Jpn J Antibiot. 1977 Dec;30 Suppl:104-20.
8
Pharmacology and chemistry of some inhibitors of herpes replication.某些疱疹复制抑制剂的药理学与化学
J Antimicrob Chemother. 1977 Mar;3 Suppl A:23-32. doi: 10.1093/jac/3.suppl_a.23.
9
Herpes simplex virus DNA and mRNA sequences in acutely and chronically infected trigeminal ganglia of mice.小鼠急性和慢性感染三叉神经节中的单纯疱疹病毒DNA和mRNA序列
Virology. 1978 Aug;89(1):102-11. doi: 10.1016/0042-6822(78)90044-2.
10
Latent characteristics of selected herpesviruses.所选疱疹病毒的潜在特征。
Adv Cancer Res. 1978;26:227-56. doi: 10.1016/s0065-230x(08)60089-5.