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口服阿昔洛韦和溴乙烯脱氧尿苷对小鼠单纯疱疹病毒潜伏感染建立及维持的影响。

Effects of oral treatment with acyclovir and bromovinyldeoxyuridine on the establishment of maintenance of latent herpes simplex virus infection in mice.

作者信息

Field H J, De Clercq E

出版信息

J Gen Virol. 1981 Oct;56(Pt 2):259-65. doi: 10.1099/0022-1317-56-2-259.

DOI:10.1099/0022-1317-56-2-259
PMID:6273499
Abstract

Mice infected with herpes simplex virus (HSV) were treated (separately) with the nucleoside analogues acyclovir or bromovinyldeoxyuridine by incorporating the drugs in the drinking water. This method of treatment was found to be effective for both drugs and compared favourably with intraperitoneal injection. Prompt treatment with either compound could prevent the establishment of latent infections but latent infections once established were intractable using prolonged courses of oral administration.

摘要

用核苷类似物阿昔洛韦或溴乙烯脱氧尿苷通过将药物加入饮用水中（分别）治疗感染单纯疱疹病毒（HSV）的小鼠。发现这种治疗方法对两种药物均有效，并且与腹腔注射相比具有优势。用这两种化合物中的任何一种进行及时治疗都可以预防潜伏感染的建立，但一旦建立潜伏感染，使用延长疗程的口服给药则难以治愈。

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Effects of oral treatment with acyclovir and bromovinyldeoxyuridine on the establishment of maintenance of latent herpes simplex virus infection in mice.口服阿昔洛韦和溴乙烯脱氧尿苷对小鼠单纯疱疹病毒潜伏感染建立及维持的影响。
J Gen Virol. 1981 Oct;56(Pt 2):259-65. doi: 10.1099/0022-1317-56-2-259.
2
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