Klareskog L, Johnell O, Hulth A, Holmdahl R, Rubin K
Arthritis Rheum. 1986 Jun;29(6):730-8. doi: 10.1002/art.1780290605.
Monoclonal antibodies to 3 different epitopes on native type II collagen were used for immunohistochemical analysis of antigenic determinants that are exposed in the cartilage and synovial tissue obtained from patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Two of the monoclonal antibodies reacted with cartilage from both OA and RA joints, but not with that from normal joints. The third monoclonal did not stain any of the cartilage sections. The 2 positive antibodies also reacted with cartilage fragments in the synovial tissue of both RA and OA joints, and in RA pannus tissue, the antibodies showed intracellular staining in many class II transplantation antigen-expressing synovial cells lying close to the damaged cartilage.
针对天然II型胶原蛋白上3种不同表位的单克隆抗体，用于对类风湿性关节炎（RA）和骨关节炎（OA）患者的软骨及滑膜组织中暴露的抗原决定簇进行免疫组织化学分析。其中两种单克隆抗体与OA和RA关节的软骨发生反应，但与正常关节的软骨无反应。第三种单克隆抗体未对任何软骨切片染色。这两种阳性抗体也与RA和OA关节滑膜组织中的软骨碎片发生反应，并且在RA血管翳组织中，抗体在靠近受损软骨的许多表达II类移植抗原的滑膜细胞中显示出细胞内染色。
