一种新型小分子与流感 A 病毒 RNA 启动子结合，抑制病毒复制。
A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication.
机构信息
Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195, USA.
出版信息
Chem Commun (Camb). 2014 Jan 11;50(3):368-70. doi: 10.1039/c3cc46973e. Epub 2013 Nov 18.
Abstract
Through screening by NMR spectroscopy, we discovered a novel scaffold (DPQ: 6,7-dimethoxy-2-(1-piperazinyl)-4-quinazolinamine) that binds specifically to the influenza A virus RNA promoter. The solution structure of the RNA-DPQ complex reported here demonstrates that the internal loop is the binding site of DPQ. The scaffold exhibits antiviral activity against influenza viruses.
摘要
通过 NMR 光谱筛选，我们发现了一种新型支架（DPQ：6,7-二甲氧基-2-(1-哌嗪基)-4-喹唑啉胺），它可特异性结合流感 A 病毒 RNA 启动子。本文报道的 RNA-DPQ 复合物的溶液结构表明，内部环是 DPQ 的结合位点。该支架对流感病毒表现出抗病毒活性。
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