IBB-Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal.
Eur J Clin Microbiol Infect Dis. 2014 May;33(5):673-88. doi: 10.1007/s10096-013-2009-3. Epub 2013 Nov 19.
Candida species belong to the normal microbiota of the oral cavity and gastrointestinal and vaginal tracts, and are responsible for several clinical manifestations, from mucocutaneous overgrowth to bloodstream infections. Once believed to be non-pathogenic, Candida glabrata was rapidly blamable for many human diseases. Year after year, these pathological circumstances are more recurrent and problematic to treat, especially when patients reveal any level of immunosuppression. These difficulties arise from the capacity of C. glabrata to form biofilms and also from its high resistance to traditional antifungal therapies. Thus, this review intends to present an excerpt of the biology, epidemiology, and pathology of C. glabrata, and detail an approach to its resistance mechanisms based on studies carried out up to the present.
假丝酵母菌属是口腔、胃肠道和阴道正常微生物群的一部分，可引起多种临床表现，从黏膜过度生长到血流感染。过去认为无致病性的光滑假丝酵母菌，近年来迅速成为许多人类疾病的罪魁祸首。年复一年，这些病理情况更频繁且更难治疗，尤其是当患者出现任何程度的免疫抑制时。这些困难源于光滑假丝酵母菌形成生物膜的能力，以及其对传统抗真菌治疗的高度耐药性。因此，本综述旨在介绍光滑假丝酵母菌的生物学、流行病学和病理学的一个摘要，并详细介绍根据目前为止的研究，对其耐药机制的研究方法。
