Nguyen Khoi-Nguyen, Sao Leena, Kyllo Kevin, Hernandez Danitza, Salomon Samantha, Shah Kalp, Oh Dahyun, Kao Katy C
Department of Chemical and Materials Engineering, San Jose State University, San Jose 95112-3613, California, United States.
ACS Omega. 2024 Oct 3;9(41):42593-42601. doi: 10.1021/acsomega.4c07869. eCollection 2024 Oct 15.
Coatings with antibiofilm properties are desirable for biomedical applications. Titanium dioxide (TiO) has been explored as an antimicrobial agent in materials development primarily due to it being an excellent photocatalyst. () is an emerging human fungal pathogen with known high resistance to oxidative stress. Here, we fabricated a polydimethylsiloxane/titanium dioxide (PDMS/TiO) nanocomposite coating and tested its antibiofilm activities against . The resulting nanocomposite exhibited >50% reduction in biofilm formation with 2.5 wt % TiO loading, even in the dark. Through ROS detection and surface characterization, the antibiofilm activity was attributed to the synergistic interaction of TiO nanoparticles with the PDMS matrix, which resulted in the impediment of hydrophobic recovery. This work provides a design strategy to develop antibiofilm coatings against .
具有抗生物膜特性的涂层在生物医学应用中很受欢迎。二氧化钛（TiO₂）主要因其是一种出色的光催化剂，已在材料开发中作为抗菌剂进行了探索。（某真菌名称未给出）是一种新兴的人类真菌病原体，已知对氧化应激具有高抗性。在此，我们制备了聚二甲基硅氧烷/二氧化钛（PDMS/TiO₂）纳米复合涂层，并测试了其对（某真菌名称未给出）的抗生物膜活性。即使在黑暗中，当二氧化钛负载量为2.5 wt%时，所得纳米复合材料的生物膜形成减少了50%以上。通过活性氧检测和表面表征，抗生物膜活性归因于二氧化钛纳米颗粒与聚二甲基硅氧烷基质的协同相互作用，这导致了疏水恢复的阻碍。这项工作提供了一种针对（某真菌名称未给出）开发抗生物膜涂层的设计策略。
