Division of Mucosal Immunology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan; Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan; Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Osaka, Japan.
J Gastroenterol Hepatol. 2013 Dec;28 Suppl 4:18-24. doi: 10.1111/jgh.12259.
The gut is equipped with a unique immune system for maintaining immunological homeostasis, and its functional immune disruption can result in the development of immune diseases such as food allergy and intestinal inflammation. Accumulating evidence has demonstrated that nutritional components play an important role in the regulation of gut immune responses and also in the development of intestinal immune diseases. In this review, we focus on the immunological functions of lipids, vitamins, and nucleotides in the regulation of the intestinal immune system and as potential targets for the control of intestinal immune diseases.
肠道配备了独特的免疫系统，以维持免疫稳态，其功能性免疫紊乱可导致免疫疾病的发展，如食物过敏和肠道炎症。越来越多的证据表明，营养成分在调节肠道免疫反应和肠道免疫疾病的发展中起着重要作用。在这篇综述中，我们重点讨论了脂质、维生素和核苷酸在调节肠道免疫系统中的免疫功能，以及作为控制肠道免疫疾病的潜在靶点。
