Laboratory of Vaccine Materials, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka, Japan; Graduate School of Medicine, Osaka University, Suita, Japan; Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan; Graduate School of Dentistry, Osaka University, Suita, Japan; Graduate School of Medicine, Kobe University, Kobe, Japan; Division of Mucosal Immunology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Division of Mucosal Immunology, International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Department of Immunology, Graduate School of Medicine, Chiba University, Chiba, Japan.
Front Nutr. 2016 Jan 27;3:3. doi: 10.3389/fnut.2016.00003. eCollection 2016.
The intestinal immune system ingeniously balances the distinct responses of elimination and tolerance of non-self-substances for the creation and maintenance of homeostatic environments. Accumulating evidence has recently shown that various lipids, including dietary one, are involved in the regulation of intestinal immunity and are associated with biophylaxis and immune disorders. Recent advances in the lipidomics allow the identification of novel pathways of lipid metabolism and lipid metabolites for the control of intestinal immunity. In this paper, we describe the effects and functions of lipids, especially sphingolipids and new lipid metabolites originated from dietary oil on the immunomodulation and on the development and pathogenesis of allergic diseases in the intestine.
肠道免疫系统巧妙地平衡了对非自身物质的消除和耐受反应，从而创造和维持了体内平衡的环境。最近的研究证据表明，各种脂质，包括膳食脂质，参与了肠道免疫的调节，并与生物保护和免疫紊乱有关。脂质组学的最新进展使得能够确定脂质代谢和脂质代谢物的新途径，以控制肠道免疫。本文描述了脂质，特别是鞘脂和来源于膳食油的新脂质代谢物对肠道免疫的调节作用及其在过敏性疾病的发生和发展中的作用和功能。
