维生素在肠道免疫监视调节和免疫稳态维持中的特定作用
The Specific Roles of Vitamins in the Regulation of Immunosurveillance and Maintenance of Immunologic Homeostasis in the Gut.
作者信息
Hosomi Koji, Kunisawa Jun
机构信息
Laboratory of Vaccine Materials, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.
Laboratory of Vaccine Materials, National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Osaka 567-0085, Japan.; Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, Graduate School of Dentistry, Osaka University, Osaka 565-0871, Japan.; Division of Mucosal Immunology, Department of Microbiology and Immunology and International Research and Development Center for Mucosal Vaccines, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan.; Department of Microbiology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017, Japan.
出版信息
Immune Netw. 2017 Feb;17(1):13-19. doi: 10.4110/in.2017.17.1.13. Epub 2017 Feb 23.
Vitamins are micronutrients which are essential for the maintenance of biological responses including immune system. Hence, vitamin deficiency increases a risk of infectious, allergic, and inflammatory diseases. Accumulating evidence has recently revealed the molecular and cellular mechanisms of vitamin-mediated regulation in the active and quiescent immune responses. In this review, we focus on the immunologic roles of vitamins in the regulation of homeostasis and surveillance in the gut.
维生素是维持包括免疫系统在内的生物反应所必需的微量营养素。因此，维生素缺乏会增加感染性、过敏性和炎症性疾病的风险。最近，越来越多的证据揭示了维生素在活跃和静止免疫反应中介导调节的分子和细胞机制。在这篇综述中，我们重点关注维生素在肠道稳态调节和监测中的免疫作用。
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