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法布雷-拉科肖特综合征:一种使用二氧化碳激光的新型两步治疗方法。

Favre-Racouchot syndrome: a novel two-step treatment approach using the carbon dioxide laser.

机构信息

The Laser Division, Salford Royal Hospital, Stott Lane, Salford, Manchester, M6 8HD, U.K.

出版信息

Br J Dermatol. 2014 Mar;170(3):657-60. doi: 10.1111/bjd.12742.

Abstract

BACKGROUND

Favre-Racouchot syndrome (FRS) is both disfiguring and difficult to treat. Available medical and surgical therapies are of variable efficacy. Most treatments do not achieve complete resolution and do not show maintenance of therapeutic response.

OBJECTIVES

To assess the response to a novel two-step treatment using the CO2 laser in patients with FRS.

METHODS

Seven patients with FRS were treated with the CO2 laser in resurfacing mode with manual expression of comedones under infiltrative local anaesthesia. The procedure was completed in one treatment session lasting 30 min and the wound was left to heal by secondary intention. A topical antibiotic was applied to treated areas, which were covered with a nonadherent dressing. All patients were assessed 3 months postoperatively by the operating laser surgeon and a visual assessment of clinical response to treatment in comparison with pretreatment photographs was made. Patient satisfaction was also recorded.

RESULTS

All patients achieved complete resolution of FRS. The follow-up duration for our cohort ranged from 8 months to 3 years. Two patients required further treatment within a 2-3-year period from initial treatment. Disease relapse was noted over 1 year after the primary treatment; both these cases were smokers and repeat treatment with similar laser parameters maintained reproducible results. Our longest disease-free follow-up duration was 3 years postprimary treatment. The laser surgeons and patients reported high levels of therapeutic benefit and satisfaction with the results.

CONCLUSIONS

This two-step treatment of FRS (CO2 laser resurfacing and manual pressure-induced expression of comedones) is an effective and durable treatment for FRS with an excellent cosmetic outcome. Long-term follow-up beyond 3 years is planned to determine whether later recurrence occurs with this technique.

摘要

背景

法夫雷-拉科肖特综合征(FRS)不仅影响容貌,而且难以治疗。现有的医学和手术疗法疗效不一。大多数治疗方法无法完全缓解症状,也无法保持治疗效果。

目的

评估 CO2 激光在 FRS 患者中应用两步治疗的效果。

方法

7 例 FRS 患者在局部浸润麻醉下使用 CO2 激光进行换肤治疗,手动挤压粉刺。整个过程在一次治疗中完成,持续 30 分钟,伤口自然愈合。治疗区域涂抹外用抗生素,并用非粘性敷料覆盖。所有患者均在术后 3 个月由手术激光外科医生进行评估,并与治疗前照片比较,评估临床治疗反应的视觉效果。同时记录患者满意度。

结果

所有患者均完全缓解 FRS。本队列的随访时间范围为 8 个月至 3 年。2 例患者在初始治疗后 2-3 年内需要进一步治疗。初次治疗后 1 年以上出现疾病复发;这两例患者均为吸烟者,使用类似的激光参数进行重复治疗可维持可重复的结果。我们最长的无疾病随访时间为初次治疗后 3 年。激光外科医生和患者均报告了较高的治疗效果和对结果的满意度。

结论

两步法治疗 FRS(CO2 激光换肤和手动挤压粉刺)是一种有效且持久的治疗 FRS 的方法,具有极好的美容效果。计划进行超过 3 年的长期随访,以确定该技术是否会出现后期复发。

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