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首次从家犬体内分离出回归热螺旋体——赫氏疏螺旋体。

First isolation of the relapsing fever spirochete, Borrelia hermsii, from a domestic dog.

作者信息

Kelly Ashley L, Raffel Sandra J, Fischer Robert J, Bellinghausen Michael, Stevenson Connie, Schwan Tom G

机构信息

Laboratory of Zoonotic Pathogens, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 South 4th Street, Hamilton, MT 59840, USA.

Kenmore Veterinary Hospital, Kenmore, WA, USA.

出版信息

Ticks Tick Borne Dis. 2014 Mar;5(2):95-9. doi: 10.1016/j.ttbdis.2013.08.005. Epub 2013 Nov 16.

DOI:10.1016/j.ttbdis.2013.08.005
PMID:24252262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3946889/
Abstract

In North America, tick-borne relapsing fever of humans is most frequently caused by infection with the spirochete Borrelia hermsii. Prior to our investigation, this spirochete was not known to infect dogs although another species, Borrelia turicatae, has been isolated from domestic canids in Florida and Texas. A clinically ill dog in Washington, USA, was spirochetemic upon examination. Spirochetes were isolated from the dog's serum and examined by PCR and multi-locus sequence typing. DNA sequences for 7 loci all typed the spirochete as B. hermsii and a member of genomic group II of this species. Therefore, companion dogs that reside in rustic cabins in higher elevation forests are at risk of infection with B. hermsii.

摘要

在北美,人类蜱传回归热最常见的病因是感染螺旋体赫氏疏螺旋体。在我们开展调查之前,尽管另一种螺旋体——杜氏疏螺旋体已从佛罗里达州和得克萨斯州的家养犬科动物中分离出来,但人们尚不知道这种螺旋体可感染犬类。美国华盛顿州一只出现临床症状的犬在检查时发现有螺旋体血症。从该犬的血清中分离出螺旋体,并通过聚合酶链反应(PCR)和多位点序列分型进行检测。7个基因座的DNA序列均将该螺旋体鉴定为赫氏疏螺旋体,且属于该物种基因组第二组的成员。因此,居住在海拔较高森林中的乡村木屋中的宠物犬有感染赫氏疏螺旋体的风险。

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本文引用的文献

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Borrelia hermsii acquisition order in superinfected ticks determines transmission efficiency.伯氏疏螺旋体在重复感染的蜱中的获取顺序决定了传播效率。
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Spirochetemia caused by Borrelia turicatae infection in 3 dogs in Texas.德克萨斯州3只狗感染图氏疏螺旋体导致螺旋体血症。
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Infect Immun. 2005 Oct;73(10):6647-58. doi: 10.1128/IAI.73.10.6647-6658.2005.