基底前脑神经元为灵长类动物新皮层提供主要的胆碱能神经支配。

Basal forebrain neurons provide major cholinergic innervation of primate neocortex.

作者信息

Struble R G, Lehmann J, Mitchell S J, McKinney M, Price D L, Coyle J T, DeLong M R

出版信息

Neurosci Lett. 1986 May 15;66(2):215-20. doi: 10.1016/0304-3940(86)90193-x.

Abstract

In 3 monkeys, lesions were made in the basal forebrain by microinjections of ibotenic acid into the nucleus basalis. Bilateral samples of multiple neocortical gyri were assayed for the activity of choline acetyltransferase. Compared to control hemispheres, enzyme activity was reduced up to 69% in the neocortex ipsilateral to the lesion; in addition, acetylcholinesterase staining was decreased at the lesioned site and in the ipsilateral cortex. These results support the concept that the principal cholinergic innervation of the primate neocortex is derived from axons and nerve terminals of neurons whose perikarya are located in the basal forebrain, particularly the nucleus basalis.

摘要

在3只猴子中，通过向基底前脑的基底核微量注射鹅膏蕈氨酸来制造损伤。对多个新皮质脑回的双侧样本进行胆碱乙酰转移酶活性测定。与对照半球相比，损伤同侧新皮质中的酶活性降低了69%；此外，在损伤部位和同侧皮质中乙酰胆碱酯酶染色减少。这些结果支持了这样一种观点，即灵长类动物新皮质的主要胆碱能神经支配源自其胞体位于基底前脑、特别是基底核的神经元的轴突和神经末梢。