镉对大鼠肝肾中必需微量元素锌和铜分布的影响。

Influence of cadmium on the distribution of the essential trace elements zinc and copper in the liver and kidneys of rats.

机构信息

Division of Clincial Chemistry, School of Medical Technology, University of Occupational and Environmental Health, Yahatanishiku, 807, Kitakyushu, Japan.

出版信息

Biol Trace Elem Res. 1987 Dec;14(3):237-48. doi: 10.1007/BF02795690.

DOI:10.1007/BF02795690

PMID:24254825

Abstract

Cd induced changes of Zn and Cd distribution in the liver and kidneys were studied in relation to Cd metallothionein (MT) synthesis. Wistar male rats were given CdCl2 by sc injection of .8, 1.5, and 3.0 mg Cd/kg three times a week for three weeks. Cd levels of liver and kidneys increased with the increment of Cd dosage and 80-90% of Cd was found in the cytosol. The MT fractions contained 80-89% cytosolic Cd in the liver and 55-75% Cd in the kidneys. Zn concentrations in the liver increased following Cd administration, But Zn in the kidneys showed only slight increase. There was a distinct decrease of Cu concentration in the liver of the 3.0 mg group. In contrast, Cu concentrations in the kidneys increased about three times in the .8 and 1.5 mg Cd groups, but Cu in the 3.0 mg group showed only 1.5 times increase. The changes of these metal concentrations were observed mainly in the cytosol. Non-MT-Cd in the kidneys was maximum in the 1.5 mg group, but the 3.0 mg group showed significant decrease. In parallel with this decrease of Cd, Cu and Zn in the kidneys showed similar decrease. When the kidneys are injured, Zn and Cu appear to leak from this organ.

摘要

镉诱导的锌和镉在肝脏和肾脏中的分布变化与镉金属硫蛋白（MT）合成有关。雄性 Wistar 大鼠每周经 sc 注射三次 0.8、1.5 和 3.0mg/kg 的 CdCl2，共三周。肝脏和肾脏中的 Cd 水平随 Cd 剂量的增加而增加，80-90%的 Cd 存在于细胞质中。MT 部分在肝脏中含有 80-89%的细胞质 Cd，在肾脏中含有 55-75%的 Cd。给予 Cd 后，肝脏中的 Zn 浓度增加，但肾脏中的 Zn 仅略有增加。3.0mg 组肝脏中的 Cu 浓度明显下降。相比之下，在 0.8 和 1.5mgCd 组中，肾脏中的 Cu 浓度增加了约三倍，但 3.0mg 组中的 Cu 仅增加了 1.5 倍。这些金属浓度的变化主要发生在细胞质中。肾脏中非 MT-Cd 在 1.5mg 组中最多，但 3.0mg 组显著减少。随着 Cd 的减少，肾脏中的 Cu 和 Zn 也表现出相似的减少。当肾脏受损时，Zn 和 Cu 似乎从该器官漏出。