Stonard M D, Webb M
Chem Biol Interact. 1976 Dec;15(4):349-63. doi: 10.1016/0009-2797(76)90140-x.
The effect of long-term dietary cadmium treatment upon the distribution of the metals copper, iron and zinc has been compared in various organs of male and female rats. The renal accumulation of cadmium was similar in both sexes without a plateau being reached. In contrast, the hepatic accumulation of cadmium was higher in the female than in the male rat and a plateau was observed after 30-35 weeks of dietary cadmium treatment. Most of the cadmium which accumulated in these organs was recovered in the metallothionein fraction andthe concentration of hepatic cadmiumthionein in the female rat was correspondingly higher than in the male rat. Accumulation of cadmium was associated with an increased zinc concentration in the liver and an increased copper concentration in the kidney; these increases were correlated with increases in liver and kidney metallothioneins induced by cadmium. Uptake of cadmium into organs other than liver and kidney occurred to a small extent but was not associated with changes in the concentration of copper and zinc. Cadmium also accumulated in the intestinal mucosa where it could be recovered in a fraction corresponding to metallothionien. A loss of iron from the liver and kidney was also observed following dietary cadmium treatment and involved mainly a loss of iron from ferritin.
已比较长期膳食镉处理对雄性和雌性大鼠各器官中金属铜、铁和锌分布的影响。两性肾脏中镉的蓄积情况相似，未达到平稳状态。相比之下，雌性大鼠肝脏中镉的蓄积量高于雄性大鼠，且在膳食镉处理30 - 35周后观察到平稳状态。这些器官中蓄积的大部分镉在金属硫蛋白部分中被回收，雌性大鼠肝脏镉硫蛋白的浓度相应高于雄性大鼠。镉的蓄积与肝脏中锌浓度增加以及肾脏中铜浓度增加有关；这些增加与镉诱导的肝脏和肾脏金属硫蛋白增加相关。镉在肝脏和肾脏以外的器官中的摄取量很少，但与铜和锌浓度的变化无关。镉也在肠黏膜中蓄积，在与金属硫蛋白相对应的部分中可以回收。膳食镉处理后还观察到肝脏和肾脏中铁的流失，主要涉及铁蛋白中铁的流失。
