果蝇中干细胞和祖细胞的营养调控。
Nutritional regulation of stem and progenitor cells in Drosophila.
机构信息
Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.
出版信息
Development. 2013 Dec;140(23):4647-56. doi: 10.1242/dev.079087.
Abstract
Stem cells and their progenitors are maintained within a microenvironment, termed the niche, through local cell-cell communication. Systemic signals originating outside the niche also affect stem cell and progenitor behavior. This review summarizes studies that pertain to nutritional effects on stem and progenitor cell maintenance and proliferation in Drosophila. Multiple tissue types are discussed that utilize the insulin-related signaling pathway to convey nutritional information either directly to these progenitors or via other cell types within the niche. The concept of systemic control of these cell types is not limited to Drosophila and may be functional in vertebrate systems, including mammals.
摘要
干细胞及其祖细胞通过局部细胞间通讯维持在一个微环境中，称为生态位。起源于生态位之外的系统信号也会影响干细胞和祖细胞的行为。这篇综述总结了与营养物质对果蝇中干细胞和祖细胞维持和增殖的影响有关的研究。讨论了多种组织类型，这些组织类型利用胰岛素相关信号通路将营养信息直接传递给这些祖细胞，或通过生态位内的其他细胞类型传递。这种对这些细胞类型的系统控制的概念不仅限于果蝇，在包括哺乳动物在内的脊椎动物系统中可能也是有效的。
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