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一株伪装成AU-1样毒株的罕见人类G3P[9]轮状病毒的全基因组分析

Complete genome analysis of a rare human G3P[9] rotavirus posing as an AU-1 like strain.

作者信息

Theamboonlers Apiradee, Maiklang Ornwalan, Thongmee Thanunrat, Chieochansin Thaweesak, Vuthitanachot Viboonsuk, Poovorawan Yong

机构信息

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University and Hospital, Bangkok, 10330 Thailand.

出版信息

Springerplus. 2013 Oct 26;2:569. doi: 10.1186/2193-1801-2-569. eCollection 2013.

DOI:10.1186/2193-1801-2-569
PMID:24255863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3824699/
Abstract

BACKGROUND

We performed phylogenetic and sequence analysis by Basic Local Alignment Search Tool (BLAST) of a complete Human Rotavirus (HRV) genome isolated from a hospitalized child with acute gastroenteritis in Thailand.

FINDINGS

The results indicated an uncommon strain characterized by multiple re-assortments in the VP3, VP4, VP6, NSP1, NSP4 and NSP5 genes. The uncommon strain is genotype G3-P[9]-I3-R3-C3-M3-A3-N3-T3-E3-H6, which displays aspects of the AU-1, FRV-1 and corresponds to the feline/canine prototype G3P[9] strain.

CONCLUSIONS

The results suggested that nearly all the eleven gene segments of G3P[9] RVA strain CU365 might have originated from feline/canine RVAs (Rotavirus A).

摘要

背景

我们通过基本局部比对搜索工具（BLAST）对从泰国一名患急性肠胃炎的住院儿童分离出的完整人类轮状病毒（HRV）基因组进行了系统发育和序列分析。

研究结果

结果表明这是一种不常见的毒株，其特征是在VP3、VP4、VP6、NSP1、NSP4和NSP5基因中存在多次重配。这种不常见的毒株是基因型G3-P[9]-I3-R3-C3-M3-A3-N3-T3-E3-H6，它表现出AU-1、FRV-1的特征，并且与猫/犬原型G3P[9]毒株相对应。

结论

结果表明，G3P[9] RVA毒株CU365的几乎所有11个基因片段可能都起源于猫/犬轮状病毒A（RVA）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/3824699/0d6cb3ee8ca7/40064_2013_620_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/3824699/5fcd660a26ef/40064_2013_620_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/3824699/0d6cb3ee8ca7/40064_2013_620_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/3824699/5fcd660a26ef/40064_2013_620_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1436/3824699/0d6cb3ee8ca7/40064_2013_620_Fig2_HTML.jpg

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