从海洋海绵 Suberites mammilaris 和 Suberites japonicus 中分离得到的碘代炔酸的表征和抗炎作用。
Characterization and anti-inflammatory effects of iodinated acetylenic acids isolated from the marine sponges Suberites mammilaris and Suberites japonicus.
机构信息
Department of Oceanography, Kunsan National University , Jeonbuk, 573-701, South Korea.
出版信息
J Nat Prod. 2013 Dec 27;76(12):2355-9. doi: 10.1021/np400793r. Epub 2013 Nov 20.
The previously unknown compounds 1-4, acetylenic acids with one or two iodine atom(s), were isolated from the marine sponges Suberites mammilaris and Suberites japonicus. Their complete structures were determined using NMR and mass spectrometry. The methylated compounds 1a and 2a exhibited a strong NO inhibitory effect on RAW264.7 cells, while methylated 3a and 4a were inactive in RAW264.7 cells, but highly active in BV2 microglia cells.
从海洋海绵 Suberites mammilaris 和 Suberites japonicus 中分离得到了以前未知的化合物 1-4，它们是带有一个或两个碘原子的炔酸。使用 NMR 和质谱法确定了它们的完整结构。甲基化化合物 1a 和 2a 对 RAW264.7 细胞具有强烈的 NO 抑制作用，而甲基化 3a 和 4a 在 RAW264.7 细胞中没有活性，但在 BV2 小胶质细胞中具有高度活性。
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