Department of Obstetrics and Gynecology, Division of Infectious Diseases.
Clin Infect Dis. 2013 Dec;57 Suppl 4:S171-3. doi: 10.1093/cid/cit611.
Maternal cytomegalovirus (CMV) is the cause of the most frequent congenital infection in America; however, pregnant women are not routinely screened. Primary CMV infection is associated with a high maternal-to-child transmission rate (40%); up to 15% of these infected neonates will be symptomatic at birth and develop permanent sequelae that usually involve the central nervous system. New interventions are now available to decrease the rate of primary maternal infection as well as to treat pregnant women with primary infection, thus decreasing the fetal and neonatal morbidity associated with this disease. Based on these data, strategies for maternal screening need to be reconsidered.
巨细胞病毒（CMV）是美国最常见的先天性感染病原体，但孕妇并未常规筛查。原发性 CMV 感染与母婴传播率高（40%）有关；这些受感染的新生儿中有高达 15%会在出生时出现症状，并发展为通常涉及中枢神经系统的永久性后遗症。目前已有新的干预措施可降低原发性母体感染率，并治疗原发性感染孕妇，从而降低与该疾病相关的胎儿和新生儿发病率。基于这些数据，需要重新考虑孕妇的筛查策略。
