Okosdinossian E T, el-Munshid H A
Scand J Gastroenterol. 1977;12(8):945-50. doi: 10.3109/00365527709181354.
Five patients (four with vitiligo and one with pernicious anaemia) were subjected to the histamine infusion test; there were achlorhydric while the remaining two secreted quite small amounts of acid. [Na+],[Cl-)and[alkali]were determined in the alkaline gastric juice samples (pH greater than 7.0). In order to assess the contribution of swallowed saliva the histamine test was done twice in each patient: (A) with precautions to prevent swallowing of saliva; and (B) with the patient allowed to swallow saliva freely. In each sample reflux of duodenal juice was estimated so that its contribution to the alkaline gastric aspirate could be assessed. Such reflex was absent in one patient, negligible in another, while in the remaining three patients the mean pyloric reflux amounted to no more than 8% of the observed volume. Swallowed saliva had diluting effect on [Na+] and [Cl-] but raised K+ concentration in the alkaline gastric aspirate. The comparison of alkaline gastric juice, free to an appreciable extent of salivary contamination, was shown to be relatively constant. The results are consistent with the two-component hypothesis of gastric secretion.
五名患者（四名白癜风患者和一名恶性贫血患者）接受了组胺输注试验；他们胃酸缺乏，而其余两名患者分泌的胃酸量很少。在碱性胃液样本（pH大于7.0）中测定了[Na⁺]、[Cl⁻]和[碱]。为了评估吞咽唾液的影响，对每位患者进行了两次组胺试验：（A）采取预防措施防止吞咽唾液；（B）让患者自由吞咽唾液。在每个样本中评估十二指肠液的反流情况，以便评估其对碱性胃液抽吸物的影响。一名患者没有这种反流，另一名患者可忽略不计，而在其余三名患者中，平均幽门反流不超过观察到的胃液量的8%。吞咽的唾液对[Na⁺]和[Cl⁻]有稀释作用，但会提高碱性胃液抽吸物中的K⁺浓度。结果表明，在很大程度上不受唾液污染的碱性胃液相对稳定。这些结果与胃液分泌的双成分假说一致。
