Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim Heidelberg University, Mannheim, Germany.
Acta Psychiatr Scand. 2014 Aug;130(2):123-36. doi: 10.1111/acps.12229. Epub 2013 Nov 25.
Electroencephalographic (EEG) neurofeedback training has been shown to produce plastic modulations in salience network and default mode network functional connectivity in healthy individuals. In this study, we investigated whether a single session of neurofeedback training aimed at the voluntary reduction of alpha rhythm (8-12 Hz) amplitude would be related to differences in EEG network oscillations, functional MRI (fMRI) connectivity, and subjective measures of state anxiety and arousal in a group of individuals with post-traumatic stress disorder (PTSD).
Twenty-one individuals with PTSD related to childhood abuse underwent 30 min of EEG neurofeedback training preceded and followed by a resting-state fMRI scan.
Alpha desynchronizing neurofeedback was associated with decreased alpha amplitude during training, followed by a significant increase ('rebound') in resting-state alpha synchronization. This rebound was linked to increased calmness, greater salience network connectivity with the right insula, and enhanced default mode network connectivity with bilateral posterior cingulate, right middle frontal gyrus, and left medial prefrontal cortex.
Our study represents a first step in elucidating the potential neurobehavioural mechanisms mediating the effects of neurofeedback treatment on regulatory systems in PTSD. Moreover, it documents for the first time a spontaneous EEG 'rebound' after neurofeedback, pointing to homeostatic/compensatory mechanisms operating in the brain.
脑电图（EEG）神经反馈训练已被证明可在健康个体中产生显着网络和默认模式网络功能连接的可塑调节。在这项研究中，我们调查了单次神经反馈训练是否与 EEG 网络振荡、功能磁共振成像（fMRI）连接以及创伤后应激障碍（PTSD）个体的主观状态焦虑和唤醒测量的差异有关。
21 名与儿童期虐待有关的 PTSD 患者接受了 30 分钟的 EEG 神经反馈训练，在此之前和之后进行了静息状态 fMRI 扫描。
去同步神经反馈与训练期间的 alpha 振幅降低有关，随后在静息状态下 alpha 同步性显著增加（“反弹”）。这种反弹与平静感增加、右侧岛叶与显着网络连接增强以及双侧后扣带回、右侧额中回和左侧内侧前额叶默认模式网络连接增强有关。
我们的研究代表了阐明神经反馈治疗对 PTSD 调节系统影响的潜在神经行为机制的第一步。此外，它首次记录了神经反馈后的自发 EEG“反弹”，指向大脑中运行的同态/补偿机制。
