Clinical Research Center, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Department of Cardiovascular Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Front Immunol. 2023 Jan 5;13:1071360. doi: 10.3389/fimmu.2022.1071360. eCollection 2022.
As modern medicine began to emerge at the turn of the 20th century, glycan-based therapies advanced. DNA- and protein-centered therapies became widely available. The research and development of structurally defined carbohydrates have led to new tools and methods that have sparked interest in the therapeutic applications of glycans. One of the latest omics disciplines to emerge in the contemporary post-genomics age is glycomics. In addition, to providing hope for patients and people with different health conditions through a deeper understanding of the mechanisms of common complex diseases, this new specialty in system sciences has much to offer to communities involved in the development of diagnostics and therapeutics in medicine and life sciences.This review focuses on recent developments that have pushed glycan-based therapies into the spotlight in medicine and the technologies powering these initiatives, which we can take as the most significant success of the 21st century.
随着 20 世纪之交现代医学的兴起,基于聚糖的疗法也取得了进展。以 DNA 和蛋白质为中心的疗法变得广泛可用。对结构明确的碳水化合物的研究和开发催生了新的工具和方法,激发了人们对聚糖治疗应用的兴趣。在当代后基因组时代出现的最新组学学科之一是糖组学。此外,通过更深入地了解常见复杂疾病的机制,为患者和有不同健康状况的人带来希望,这个系统科学的新专业为参与医学和生命科学中诊断和治疗方法开发的社区提供了很多帮助。本文重点介绍了推动聚糖疗法成为医学焦点的最新进展以及推动这些举措的技术,我们可以将其视为 21 世纪最重要的成功。