Strauchen J A, Dimitriu-Bona A
Am J Pathol. 1986 Aug;124(2):303-9.
Monoclonal antibodies were used in an investigation of the histogenesis of malignant fibrous histiocytoma (MFH), a neoplasm with morphologic features of both fibroblastic and histiocytic differentiation. In 4 cases of MFH studied, the tumor cells were found to react uniformly with antibodies to determinants expressed on monocyte macrophages (T-200, Ia, MoS-1, MoS-39, MoR-17). Both spindle and histiocyte-like tumor cells expressed these markers. In contrast, in 8 non-MFH soft tissue tumors, tumor cell reactivity was not observed. The reactivity of the spindle cells of MFH for determinants of monocyte/macrophages favors their origin from tissue histiocytes (facultative fibroblasts). The results support the view that MFH is a tumor of the mononuclear phagocyte system.
单克隆抗体被用于研究恶性纤维组织细胞瘤（MFH）的组织发生，MFH是一种具有成纤维细胞和组织细胞分化形态特征的肿瘤。在研究的4例MFH中，发现肿瘤细胞与针对单核巨噬细胞上表达的决定簇的抗体呈一致反应（T - 200、Ia、MoS - 1、MoS - 39、MoR - 17）。梭形和组织细胞样肿瘤细胞均表达这些标志物。相比之下，在8例非MFH软组织肿瘤中，未观察到肿瘤细胞反应性。MFH梭形细胞对单核细胞/巨噬细胞决定簇的反应性支持它们起源于组织巨噬细胞（兼性成纤维细胞）的观点。这些结果支持MFH是单核吞噬细胞系统肿瘤的观点。
