Burgdorf W H, Duray P, Rosai J
Am J Clin Pathol. 1981 Feb;75(2):162-7. doi: 10.1093/ajcp/75.2.162.
Histiocytosis X, multicentric reticulohistiocytosis, juvenile xanthogranuloma, the "fibrous" type of dermatofibroma, dermatofibrosarcoma protuberans, and malignant fibrous histiocytoma are all characterized by dermal and/or subcutaneous infiltrates composed at least partially of cells having morphologic features suggestive of histiocytes. Paraffin-embedded tissues representing these conditions were stained for lysozyme (muramidase) with a peroxidase-antiperoxidase technic. The cells of juvenile xanthogranuloma were rich in lysozyme. Some of the cells of histiocytosis X showed a positive pattern, and the cells of the other three conditions were essentially negative. This study confirmed the histiocytic nature of juvenile xanthogranuloma and multicentric reticulohistiocytosis, supported the interpretation that there is a histiocytic component in the lesions of histiocytosis X, and cast some doubt on the alleged histiocytic nature of "fibrous" dermatofibroma, dermatofibrosarcoma protuberans, and malignant fibrous histiocytoma.
组织细胞增多症X、多中心性网状组织细胞增多症、幼年性黄色肉芽肿、“纤维性”皮肤纤维瘤、隆突性皮肤纤维肉瘤和恶性纤维组织细胞瘤均具有真皮和/或皮下浸润的特征，这些浸润至少部分由具有提示组织细胞形态特征的细胞组成。用过氧化物酶-抗过氧化物酶技术对代表这些病症的石蜡包埋组织进行溶菌酶（胞壁质酶）染色。幼年性黄色肉芽肿的细胞富含溶菌酶。组织细胞增多症X的一些细胞呈阳性模式，而其他三种病症的细胞基本为阴性。本研究证实了幼年性黄色肉芽肿和多中心性网状组织细胞增多症的组织细胞性质，支持组织细胞增多症X病变中存在组织细胞成分的解释，并对所谓的“纤维性”皮肤纤维瘤、隆突性皮肤纤维肉瘤和恶性纤维组织细胞瘤的组织细胞性质提出了一些疑问。
