Gylfe E, Larsson R, Johansson H, Nygren P, Rastad J, Wallfelt C, Akerström G
FEBS Lett. 1986 Sep 1;205(1):132-6. doi: 10.1016/0014-5793(86)80880-8.
The Ca2+ receptor mechanism of the parathyroid cell was studied using La3+ as a probe. La3+ was found to bind to the cell surface without further penetration. Measurements of 45Ca fluxes and the cytoplasmic Ca2+ concentration (Ca2+i) revealed a stimulatory component in the action of La3+ on Ca2+ permeability resulting in a rise in Ca2+i. These effects mimicked those obtained when raising the extracellular Ca2+ concentration from 0.5 to 3.0 mM, but the actions of La3+ and Ca2+ were not additive. The results suggest the existence of a novel Ca2+ permeability physiologically activated by binding of Ca2+ to an external receptor.
使用La3+作为探针研究了甲状旁腺细胞的Ca2+受体机制。发现La3+结合到细胞表面而没有进一步穿透。对45Ca通量和细胞质Ca2+浓度（Ca2+i）的测量揭示了La3+对Ca2+通透性作用中的一个刺激成分，导致Ca2+i升高。这些效应类似于将细胞外Ca2+浓度从0.5 mM提高到3.0 mM时获得的效应，但La3+和Ca2+的作用不是相加的。结果表明存在一种新型的Ca2+通透性，其通过Ca2+与外部受体结合而在生理上被激活。
