Friedrich Alexander University Erlangen-Nuremberg; Department of Biology, Chair of Microbiology; Erlangen, Germany.
Gut Microbes. 2013 Nov-Dec;4(6):454-74. doi: 10.4161/gmic.27001. Epub 2013 Nov 6.
Helicobacter pylori infections can induce pathologies ranging from chronic gastritis, peptic ulceration to gastric cancer. Bacterial isolates harbor numerous well-known adhesins, vacuolating cytotoxin VacA, protease HtrA, urease, peptidoglycan, and type IV secretion systems (T4SS). It appears that H. pylori targets more than 40 known host protein receptors on epithelial or immune cells. A series of T4SS components such as CagL, CagI, CagY, and CagA can bind to the integrin α 5β 1 receptor. Other targeted membrane-based receptors include the integrins αvβ 3, αvβ 5, and β 2 (CD18), RPTP-α/β, GP130, E-cadherin, fibronectin, laminin, CD46, CD74, ICAM1/LFA1, T-cell receptor, Toll-like receptors, and receptor tyrosine kinases EGFR, ErbB2, ErbB3, and c-Met. In addition, H. pylori is able to activate the intracellular receptors NOD1, NOD2, and NLRP3 with important roles in innate immunity. Here we review the interplay of various bacterial factors with host protein receptors. The contribution of these interactions to signal transduction and pathogenesis is discussed.
幽门螺杆菌感染可引起从慢性胃炎、消化性溃疡到胃癌等多种病理变化。细菌分离株含有许多已知的黏附素、空泡细胞毒素 VacA、蛋白酶 HtrA、脲酶、肽聚糖和 IV 型分泌系统（T4SS）。似乎幽门螺杆菌针对上皮或免疫细胞上的 40 多种已知宿主蛋白受体。一系列 T4SS 成分，如 CagL、CagI、CagY 和 CagA，可与整合素 α5β1 受体结合。其他靶向基于膜的受体包括整合素 αvβ3、αvβ5 和 β2（CD18）、RPTP-α/β、GP130、E-钙黏蛋白、纤连蛋白、层粘连蛋白、CD46、CD74、ICAM1/LFA1、T 细胞受体、Toll 样受体和受体酪氨酸激酶 EGFR、ErbB2、ErbB3 和 c-Met。此外，幽门螺杆菌还能够激活细胞内受体 NOD1、NOD2 和 NLRP3，这些受体在先天免疫中具有重要作用。在这里，我们回顾了各种细菌因子与宿主蛋白受体的相互作用。讨论了这些相互作用对信号转导和发病机制的贡献。
