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Monoclonal antibodies specific for Sendai virus. I. Production and characterization of monoclonal antibodies.

作者信息

Fenner M, Binz H

出版信息

Scand J Immunol. 1986 Sep;24(3):335-40. doi: 10.1111/j.1365-3083.1986.tb02102.x.

DOI:10.1111/j.1365-3083.1986.tb02102.x
PMID:2428098
Abstract

Twelve monoclonal antibodies specific for Sendai virus were prepared by fusing immune LOU rat spleen cells with Y3 or FO myeloma cells. Six antibodies bound the viral glycoprotein HN, and six the viral protein F. Among the six HN-specific monoclonal antibodies, five reacted with the very same epitope and inhibited viral haemagglutination. Two antibodies against the F protein recognized the same epitope, but all the others reacted with different epitopes. All monoclonals were characterized with regard to specificity, biological function, epitope recognition, isotypes, and pI.

摘要

相似文献

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Monoclonal antibodies specific for Sendai virus. I. Production and characterization of monoclonal antibodies.
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引用本文的文献

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J Virol. 1987 Aug;61(8):2624-6. doi: 10.1128/JVI.61.8.2624-2626.1987.
2
Neutralization epitopes of the F glycoprotein of respiratory syncytial virus: effect of mutation upon fusion function.呼吸道合胞病毒F糖蛋白的中和表位：突变对融合功能的影响
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