高负载量的 Ru(II) 配合物在金纳米粒子上用于细胞中单粒子发光成像。
High coating of Ru(II) complexes on gold nanoparticles for single particle luminescence imaging in cells.
机构信息
School of Chemistry, The University of Birmingham, Edgbaston, B15 2TT, UK.
出版信息
Chem Commun (Camb). 2014 Jan 18;50(5):617-9. doi: 10.1039/c3cc47606e. Epub 2013 Nov 26.
PMID:24281162
Abstract
Gold nanoparticles are efficiently labelled with a luminescent ruthenium complex, producing 13 and 100 nm diameter, monodisperse red-emissive imaging probes with luminescence lifetimes prolonged over the molecular unit. Single, 100 nm particles are observed in whole cell luminescence imaging which reveals their biomolecular association with chromatin in the nucleus of cancer cells.
摘要
金纳米颗粒被高效标记上了一种发光明亮的钌复合物，生成了 13nm 和 100nm 直径的单分散红色发光成像探针，其荧光寿命比分子单元延长了。在全细胞发光成像中观察到了单个 100nm 颗粒，这表明它们与癌细胞核内的染色质发生了生物分子结合。
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