Udobi C E, Obajuluwa A F, Onaolapo J A
Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria.
Biomed Res Int. 2013;2013:860467. doi: 10.1155/2013/860467. Epub 2013 Oct 27.
Patients with surgical wounds have been reported to be at high risk of MRSA carriage and infection. The prevalence and antibiotic resistance pattern of this organism in the orthopaedic ward of Ahmadu Bello University Teaching Hospital (ABUTH), Zaria-Nigeria, a 547-bed Nigerian hospital, were thus studied. A total of 185 isolates of Staphylococcus aureus were confirmed from 217 samples taken from the orthopaedic wards of the hospital using standard isolation methods. Out of these, 44 (23.8%) were from the wounds of patients and 70 (37.8%) from the skin. The remaining 65 (35.1%) and 6 (3.2%) were from their beds and the atmospheric air, respectively. Out of these, 33 (75%), 36 (51.4%), and 48 (73.8%) from wounds, skin, and bed, respectively, were found to be methicillin-resistant Staphylococcus aureus (MRSA) using the disc-sensitive test methods. None was detected from the atmosphere. The antibiotic susceptibility pattern results showed the level of resistance to be ampicillin 100% in all the three sites, pefloxacin 90.9%, 72.2%, 66.7%, ceftriaxone 69.7%, 72.2%, 70.8%, gentamicin 54.5%, 52.8%, 37.5%, and ciprofloxacin 51.5%, 47.2%, 35.4% at the wound, skin, and bed sites, respectively. Results confirm that MRSA continues to pose a threat to the hospitalized patients, especially those with bone and wound infections.
据报道，有手术伤口的患者感染耐甲氧西林金黄色葡萄球菌（MRSA）并携带该病菌的风险很高。因此，对尼日利亚扎里亚市阿哈迈杜·贝洛大学教学医院（ABUTH）骨科病房（一家拥有547张床位的尼日利亚医院）中该病菌的流行情况和抗生素耐药模式进行了研究。采用标准分离方法，从该医院骨科病房采集的217份样本中，共确认了185株金黄色葡萄球菌分离株。其中，44株（23.8%）来自患者伤口，70株（37.8%）来自皮肤。其余65株（35.1%）和6株（3.2%）分别来自病床和空气。在这些样本中，采用纸片敏感试验方法发现，分别有33株（75%）来自伤口、36株（51.4%）来自皮肤、48株（73.8%）来自病床的样本为耐甲氧西林金黄色葡萄球菌（MRSA）。空气中未检测到MRSA。抗生素敏感性模式结果显示，在伤口、皮肤和病床部位，对氨苄西林的耐药率均为100%，对培氟沙星的耐药率分别为90.9%、72.2%、66.7%，对头孢曲松的耐药率分别为69.7%、72.2%、70.8%，对庆大霉素的耐药率分别为54.5%、52.8%、37.5%，对环丙沙星的耐药率分别为51.5%、47.2%、35.4%。结果证实，MRSA继续对住院患者构成威胁，尤其是那些患有骨感染和伤口感染的患者。
