Wang Lin, Chen Guang-Ying, Han Chang-Ri, Yuan Yuan, Yang Biao, Zhang Yuan, Wang Jing, Zhong Xiu-Qiong, Huang Xin
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, P R China.
Chem Pharm Bull (Tokyo). 2011;59(3):338-40. doi: 10.1248/cpb.59.338.
Two novel alkaloids, saprosmine A (1) and saprosmine B (2), were isolated from the stem of Saprosma hainanense MERR., along with five known alkaloids: marcanine A (3); cleistopholine (4); 4-methoxycarbonyl-5,10-benzogquinolinequinone (5); liriodenine (6); and quinoline (7). The chemical structures were established on the basis of extensive spectroscopic (IR, 1D-NMR, 2D-NMR, MS) data analysis and by comparison with spectroscopic data reported in the literature. Compounds 1 to 6 were evaluated for in vitro cytotoxic activities against the SPC-A-1 (human lung cancer), BEL-7402 (human hepatocellular carcinoma), SGC-7901 (human gastric cancer), and K-562 (human myelogenous leukaemia) cancer cell lines. Compounds 1 and 2 exhibited weak cytotoxic activities against K-562 cells. Compounds 3 and 5 showed cytotoxic activities against all four cancer cell lines.
从海南破布木（Saprosma hainanense MERR.）的茎中分离出两种新生物碱，即破布木胺A（1）和破布木胺B（2），以及五种已知生物碱：马克宁A（3）；闭花木碱（4）；4-甲氧基羰基-5,10-苯并喹啉醌（5）；鹅掌楸碱（6）；和喹啉（7）。通过广泛的光谱（红外光谱、一维核磁共振、二维核磁共振、质谱）数据分析，并与文献报道的光谱数据进行比较，确定了化学结构。对化合物1至6进行了体外细胞毒活性评估，针对SPC-A-1（人肺癌）细胞系、BEL-7402（人肝癌）细胞系、SGC-7901（人胃癌）细胞系和K-562（人骨髓性白血病）细胞系。化合物1和2对K-562细胞表现出较弱的细胞毒活性。化合物3和5对所有四种癌细胞系均表现出细胞毒活性。
