a Laboratoire des Substances Bioactives (LSBA), Centre de Biotechnologie de Borj Cedria, BP-901, 2050 Hammam-Lif, Tunisie.
Can J Physiol Pharmacol. 2013 Dec;91(12):1076-85. doi: 10.1139/cjpp-2013-0225. Epub 2013 Sep 3.
Obesity is a public health problem contributing to morbidity and mortality from metabolic syndrome. It has long been recognized that there is a gender dependency in several obesity-related health risks. Using a high fat diet (HFD) to induce obesity in Wistar rats, we studied the gender dependency of fat-induced oxidative stress in the heart and liver, with a special emphasis on the distribution of transition metals, as well as the protective effects of grape seed and skin extract (GSSE). HFD induced obesity in both male and female rats, characterized by increased body weight as well as relative liver mass in both genders, and increased relative heart mass in the males only. HFD also provoked the accumulation of triglycerides and total cholesterol into the male hearts, and into the livers of both genders. HFD induced oxidative stress in the male hearts and also in the livers of both genders. Furthermore, HFD affected cardiac levels of copper in the males, and hepatic levels of copper and zinc in both genders, whereas HFD affected free iron in the male hearts and female livers, specifically. In conclusion, HFD treatment altered transition metal homeostasis more drastically in the male heart than in the female liver, and GSSE efficiently protected these organs against fat-induced disturbances, regardless of gender.
肥胖是一个公共卫生问题，可导致代谢综合征的发病率和死亡率升高。长期以来，人们已经认识到，在几种与肥胖相关的健康风险中存在性别依赖性。本研究使用高脂肪饮食（HFD）诱导 Wistar 大鼠肥胖，以研究脂肪诱导的心脏和肝脏氧化应激的性别依赖性，特别强调过渡金属的分布，以及葡萄籽油和皮提取物（GSSE）的保护作用。HFD 可诱导雄性和雌性大鼠肥胖，其特征为体重增加，以及两性的肝相对质量增加，而雄性的心脏相对质量仅增加。HFD 还会引起雄性心脏和两性肝脏中的甘油三酯和总胆固醇积累。HFD 可诱导雄性心脏和两性肝脏发生氧化应激。此外，HFD 影响雄性心脏中的铜和两性肝脏中的铜和锌的水平，而 HFD 具体影响雄性心脏和雌性肝脏中的游离铁。总之，HFD 处理在雄性心脏中比在雌性肝脏中更剧烈地改变了过渡金属的动态平衡，GSSE 有效地保护这些器官免受脂肪诱导的干扰，而与性别无关。
