Department of Nutrition, Department of Epidemiology, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA.
J Natl Cancer Inst. 2010 Jun 2;102(11):771-83. doi: 10.1093/jnci/djq107. Epub 2010 May 7.
The relationships between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk remain unresolved.
We investigated prospectively the association between coffee, tea, and sugar-sweetened carbonated soft drink consumption and colon cancer risk in a pooled analysis of primary data from 13 cohort studies. Among 731 441 participants followed for up to 6-20 years, 5604 incident colon cancer case patients were identified. Study-specific relative risks (RRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models and then pooled using a random-effects model. All statistical tests were two-sided.
Compared with nonconsumers, the pooled multivariable relative risks were 1.07 (95% CI = 0.89 to 1.30, P(trend) = .68) for coffee consumption greater than 1400 g/d (about six 8-oz cups) and 1.28 (95% CI = 1.02 to 1.61, P(trend) = .01) for tea consumption greater than 900 g/d (about four 8-oz cups). For sugar-sweetened carbonated soft drink consumption, the pooled multivariable relative risk comparing consumption greater than 550 g/d (about 18 oz) to nonconsumers was 0.94 (95% CI = 0.66 to 1.32, P(trend) = .91). No statistically significant between-studies heterogeneity was observed for the highest category of each beverage consumed (P > .20). The observed associations did not differ by sex, smoking status, alcohol consumption, body mass index, physical activity, or tumor site (P > .05).
Drinking coffee or sugar-sweetened carbonated soft drinks was not associated with colon cancer risk. However, a modest positive association with higher tea consumption is possible and requires further study.
咖啡、茶和加糖碳酸软饮料的消费与结肠癌风险之间的关系仍未解决。
我们通过对 13 项队列研究的原始数据进行汇总分析，前瞻性地研究了咖啡、茶和加糖碳酸软饮料的消费与结肠癌风险之间的关系。在随访时间长达 6-20 年的 731441 名参与者中，共发现了 5604 例结肠癌病例。使用 Cox 比例风险模型估计每个研究的相对风险（RR）和 95%置信区间（CI），然后使用随机效应模型进行汇总。所有统计检验均为双侧检验。
与不饮用者相比，每天饮用大于 1400 g（约 6 杯 8 盎司杯）咖啡和大于 900 g（约 4 杯 8 盎司杯）茶的汇总多变量 RR 分别为 1.07（95%CI=0.89 至 1.30，P（趋势）=0.68）和 1.28（95%CI=1.02 至 1.61，P（趋势）=0.01）。对于含糖碳酸软饮料的消费，与不饮用者相比，每天饮用大于 550 g（约 18 盎司）的汇总多变量 RR 为 0.94（95%CI=0.66 至 1.32，P（趋势）=0.91）。对于每种饮料的最高摄入量，未观察到研究间存在统计学显著的异质性（P>0.20）。观察到的关联在性别、吸烟状况、饮酒、体重指数、身体活动或肿瘤部位方面没有差异（P>0.05）。
饮用咖啡或含糖碳酸软饮料与结肠癌风险无关。然而，饮用更多茶可能与结肠癌风险呈适度正相关，需要进一步研究。
