Gallicchio Lisa, Calhoun Carla, Helzlsouer Kathy J
The Prevention and Research Center, The Weinberg Center for Women's Health and Medicine, Mercy Medical Center, 227 St. Paul Place, Baltimore, MD, 21202, USA,
Support Care Cancer. 2014 Apr;22(4):1081-8. doi: 10.1007/s00520-013-2066-2. Epub 2013 Nov 29.
The goal of this study was to examine differences in physical functioning limitations among African-American and white breast cancer survivors.
Data were analyzed from 115 African-American and 712 white breast cancer survivors who responded to a hospital registry-based survey. Physical functioning limitations were assessed using a series of eight questions in which individuals were asked about their ability to perform a physical task such as walking a quarter of a mile. A four-category summary score, representing overall severity of limitation, was created using participant responses to the eight questions. Ordinal logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for the association between race and physical functioning limitation adjusted for potential confounders.
In the unadjusted model, the African-American breast cancer survivors were more than twice as likely to have a greater degree of physical functioning limitation compared to their white counterparts (OR 2.31; 95% CI 1.59, 3.38). After adjustment for covariates, including body mass index (BMI), the race OR was attenuated and no longer statistically significant (OR 1.44; 95% CI 0.92, 2.27).
Findings from this study showed that African-American breast cancer survivors were more likely to have worse physical functioning limitations than their white counterparts; however, much of this disparity was due to racial differences in other variables such as BMI. Future research should focus on effective interventions targeting modifiable risk factors of physical functioning limitations among breast cancer survivors with the goal of improving quality of life.
本研究的目的是检验非裔美国乳腺癌幸存者与白人乳腺癌幸存者在身体功能受限方面的差异。
对115名非裔美国乳腺癌幸存者和712名白人乳腺癌幸存者的数据进行分析，这些数据来自基于医院登记处的调查。身体功能受限情况通过一系列八个问题进行评估，这些问题询问个体执行诸如走四分之一英里等身体任务的能力。使用参与者对这八个问题的回答创建了一个代表受限总体严重程度的四类汇总分数。使用有序逻辑回归来估计种族与身体功能受限之间关联的优势比（OR）和95%置信区间（CI），并对潜在混杂因素进行了调整。
在未调整模型中，与白人乳腺癌幸存者相比，非裔美国乳腺癌幸存者身体功能受限程度更高的可能性是其两倍多（OR 2.31；95% CI 1.59，3.38）。在对包括体重指数（BMI）在内的协变量进行调整后，种族OR减弱且不再具有统计学意义（OR 1.44；95% CI 0.92，2.27）。
本研究结果表明，非裔美国乳腺癌幸存者比白人乳腺癌幸存者更有可能存在更严重的身体功能受限；然而，这种差异很大程度上是由于BMI等其他变量的种族差异。未来的研究应专注于针对乳腺癌幸存者身体功能受限的可改变风险因素的有效干预措施，以提高生活质量为目标。
