伊朗阿瓦士地区HIV阳性和HIV阴性非法药物使用者弓形虫血清学的比较研究
Comparative study on toxoplasma serology among HIV positive and HIV negative illicit drug users in Ahvaz, Iran.
作者信息
Alavi Seyed Mohammad, Jamshidian Ramin, Salmanzadeh Shokrolah
机构信息
Jundishapur Infectious and Tropical Diseases Research Center, Joundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Caspian J Intern Med. 2013 Fall;4(4):781-4.
BACKGROUND
Toxoplasmosis is a common parasitic infection in human around the world and can cause life-threatening encephalitis in human immunodeficiency virus (HIV) infected host. The aim of this study was to assess the frequency of toxoplasma infection in illicit drug users (IDUs) with and without HIV infection in Iran.
METHODS
This study was carried out on 84 IDUs (42 HIV positive as case group and 42 HIV negative subjects as control group) from 2008 to 2009. Serum samples were tested for T. gondii IgG antibodies by Enzym linked immunosorbant assay (ELISA). Based on the company brochure kit, the test was defined positive if the antibody titer was 3 IU/ml or more. The data from these two groups were collected and analyzed.
RESULTS
The mean age of HIV positive cases was 34.4±8.6 and for HIV negative cases was 35.9±9.3 year. The mean age and distribution of sex in both groups were equal. The frequency of toxoplasma-IgG in HIV positive and HIV negative was 73.8% and 81%, respectively (p=0.19).
CONCLUSION
The results show that prevalence of toxoplasmosis infection in the illicit drug users with HIV positive or negative is equal.
背景
弓形虫病是一种全球范围内常见的人类寄生虫感染，可在感染人类免疫缺陷病毒（HIV）的宿主中引发危及生命的脑炎。本研究旨在评估伊朗感染和未感染HIV的吸毒者中弓形虫感染的频率。
方法
本研究在2008年至2009年期间对84名吸毒者进行（42名HIV阳性者作为病例组，42名HIV阴性者作为对照组）。采用酶联免疫吸附测定（ELISA）检测血清样本中的弓形虫IgG抗体。根据试剂盒说明书，抗体滴度为3 IU/ml或更高时检测结果定义为阳性。收集并分析两组数据。
结果
HIV阳性病例的平均年龄为34.4±8.6岁，HIV阴性病例的平均年龄为35.9±9.3岁。两组的平均年龄和性别分布相同。HIV阳性和阴性者中弓形虫IgG的频率分别为73.8%和81%（p = 0.19）。
结论
结果表明，HIV阳性或阴性的吸毒者中弓形虫病感染率相同。
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