Department of Ophthalmology, Sapienza University of Rome, 15500161 Rome, Italy ; Servizio di Immunovirologia Oculare, Sapienza Università di Roma, Viale del Policlinico, 15500161 Rome, Italy.
Biomed Res Int. 2013;2013:284821. doi: 10.1155/2013/284821. Epub 2013 Nov 5.
To correlate the uveitic epiretinal membrane (ERM) features using spectral-domain optical coherence tomography (SD-OCT) with visual acuity (VA).
Forty-one eyes of 32 patients were included in this retrospective study. SD-OCT was performed in all patients and data were collected at the time of ERM diagnosis and at the final visit. Both best corrected visual acuity (BCVA) and ERM thickness were correlated with the morphological and clinical features.
Final BCVA was positively correlated with male sex (P = 0.0055) and the focal pattern of ERM attachment (P = 0.031) and negatively correlated with IS/OS photoreceptor junction disruption (P = 0.042). BVCA change showed a positive correlation with the age of ERM onset (P = 0.056) but a negative correlation with IS/OS photoreceptor disruption at the ERM diagnosis (P = 0.029) and the increase of central subfield thickness (CST) (P = 0.95). Final ERM thickness correlated with the duration of uveitis (P = 0.0023) and the duration of ERM (P = 1.15 e-05). During the follow-up, ERM thickening correlated with male sex (P = 0.042), posterior uveitis (P = 0.036), uveitis duration (P = 0.026), and broad attachment pattern (P = 0.052).
In the uveitic ERM, VA negatively correlates with IS/OS photoreceptor junction disruption and the increase of CST. ERM thickness is influenced by longer duration of both uveitis and ERM.
通过频域光相干断层扫描（SD-OCT）与视力（VA）相关联，分析葡萄膜炎性视网膜内表面膜（ERM）的特征。
本回顾性研究共纳入 32 例 41 只眼的患者。所有患者均行 SD-OCT 检查，并在 ERM 诊断时和最终就诊时采集数据。将最佳矫正视力（BCVA）和 ERM 厚度与形态学和临床特征相关联。
最终 BCVA 与男性（P=0.0055）和 ERM 附着的局灶性模式（P=0.031）呈正相关，与 IS/OS 光感受器连接中断（P=0.042）呈负相关。BCVA 变化与 ERM 发病年龄呈正相关（P=0.056），但与 ERM 诊断时 IS/OS 光感受器破坏（P=0.029）和中央子场厚度（CST）增加（P=0.95）呈负相关。最终 ERM 厚度与葡萄膜炎持续时间（P=0.0023）和 ERM 持续时间（P=1.15×10-5）相关。在随访期间，ERM 增厚与男性（P=0.042）、后葡萄膜炎（P=0.036）、葡萄膜炎持续时间（P=0.026）和广泛附着模式（P=0.052）相关。
在葡萄膜炎性 ERM 中，VA 与 IS/OS 光感受器连接中断和 CST 增加呈负相关。ERM 厚度受葡萄膜炎和 ERM 持续时间的影响。
