从苦参中提取的二苯甲酰基和异黄酮苷类化合物：抑制 D-半乳糖胺对人肝细胞 HL-7702 的细胞毒性作用。
Dibenzoyl and isoflavonoid glycosides from Sophora flavescens: inhibition of the cytotoxic effect of D-galactosamine on human hepatocyte HL-7702.
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
出版信息
J Nat Prod. 2013 Dec 27;76(12):2337-45. doi: 10.1021/np400784v. Epub 2013 Dec 2.
Twelve new dibenzoyl derivatives sophodibenzoside A-L (1-12) and five new isoflavone glycosides (13-17) have been isolated from the roots of Sophora flavescens together with eight known compounds (18-25). Notably, the use of acetic acid-d4 was required to enable identification of the dibenzoyl glycoside structures. Compounds 1, 2, 13, 14, and 19 exhibited weak inhibition of the cytotoxic effect of d-galactosamine on the human hepatic cell line HL-7702.
从苦豆子根中分离得到了 12 个新的二苯甲酰基衍生物 sophodibenzoside A-L（1-12）和 5 个新的异黄酮糖苷（13-17），以及 8 个已知化合物（18-25）。值得注意的是，需要使用乙酸-d4 来鉴定二苯甲酰基糖苷的结构。化合物 1、2、13、14 和 19 对 d-半乳糖胺对人肝细胞系 HL-7702 的细胞毒性有较弱的抑制作用。
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