Iantorno Micaela, Weiss Robert G
Critical Care Medicine Department, National Institutes of Health, 10 Center Drive, Room 2C145, Bethesda, MD, USA; Department of Medicine, Cardiology Division, The Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21205 USA.
Department of Medicine, Cardiology Division, The Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21205 USA.
Trends Cardiovasc Med. 2014 May;24(4):149-56. doi: 10.1016/j.tcm.2013.10.001. Epub 2013 Oct 16.
Cardiovascular disease remains the number one cause of death in the US annually. The development in recent years of imaging strategies that can identify coronary endothelial dysfunction noninvasively provides new information about the early presence and local spatial heterogeneity of endothelial function in patients with, and those at risk for, coronary artery disease. In this article, we will briefly review the mechanisms relating endothelial function and atherosclerosis, contemporary imaging strategies now able to quantify coronary endothelial function noninvasively, and recent insights on human coronary endothelial function.
心血管疾病仍然是美国每年的首要死因。近年来能够无创识别冠状动脉内皮功能障碍的成像技术发展，为冠心病患者及高危人群内皮功能的早期存在和局部空间异质性提供了新信息。在本文中，我们将简要回顾内皮功能与动脉粥样硬化相关的机制、目前能够无创量化冠状动脉内皮功能的当代成像技术，以及对人类冠状动脉内皮功能的最新见解。
